According to an animal study published in Scientific Reports, if taken together with lipids CBD has a higher chance to follow the lymphatic transport. The study found that the CBD concentrations in the lymph were 250-fold higher than in plasma. This means that if taken with a high-fat meal, the oral administration of CBD is more effective.
Higher CBD levels compared to plasma.
Furthermore, studies show that when CBD is ingested together with lipids, it is better absorbed into the lymphatic system. So, it is advisable to take your CBD after a high-fat meal.
2. Smoking CBD
The very first pharmacological effect of CBD ever observed was related to drug interaction. CBD is both a substrate and an inhibitor of CYP450 enzymes, so it could interfere with the metabolism of other drugs.
One study examined the potential drug interactions between a THC/CBD oromucosal spray and CYP450 inducers and inhibitors in various dose regimens. The study done on healthy male subjects showed that inducers of CYP3A4, an enzyme involved in the metabolism of CBD significantly reduced the peak plasma concentration of CBD. On the other hand, a CYP3A4 inhibitor nearly doubled the peak plasma concentration of CBD .
When taking CBD through the mouth after a high-fat meal, the absorption of CBD in the intestinal lymphatic system in much higher and shows potential for the treatment of autoimmune diseases. 
The metabolic process of CBD and other drugs that get broken down by gut and/or liver enzymes is known as the “first-pass” metabolism.
Although that outlines the basic journey of CBD, what we’re interested in is how long the interaction between CBD metabolites and receptors last—how long CBD stays in your system. To understand that, we need to explain the concept of “half-life”.
• Purity and strength of the oil/supplement you’re using
How is CBD processed?
Half-life is typically measured by administering a single dose of a compound, then testing blood plasma for traces of the drug at regular intervals. The amount of the drug in the plasma will usually increase, reach a peak, and then start to decline.
But, and this is an important but, that timescale will vary from one person to the next. How long CBD stays in your system is also affected by several biological factors, as well as the way you consume it.
Our metabolism is a combination of chemical reactions, one of which includes the conversion of food to energy. The faster your metabolism, the quicker substances (including CBD) are broken down, processed and eliminated.
No , drug tests do not screen for CBD, so you don’t have to worry about how long CBD is detectable in urine. Drug tests only screen for THC and its related metabolites in urine, blood, or hair.
The effects of CBD typically last 5-6 hours . However, it depends on the dose and type of CBD. The effects of pure or refined CBD oil will last longer. Once it is initially absorbed, the concentration of CBD in the blood drops hour-by-hour, so larger doses will also last longer.
CBD oil vs. Hemp oil vs. THC oil: what’s the difference?
CBD oil is an oil that contains concentrated cannabidiol, or CBD, which is extracted from the leaves and stem of the hemp plant. CBD oil is non-psychoactive, and is a powerful anti-inflammatory that provides a range of medical benefits.
CBD can be taken both topically and orally. If you are using CBD for joint pain, muscle soreness, or skin problems, then you apply a topical balm or lotion directly to the body part.
You shouldn’t have to worry about exactly how long CBD will stay in your system, since: