Conclusion: CBD may help with depression but more trials are needed.
Conclusion: Topical CBD may be beneficial at relieving arthritis but no high-quality human studies prove this.
Other research (both animal and human) has shown that CBD has anti-inflammatory effects, and it may relieve pain by this mechanism.
CBD can interact with other medications used to treat heart conditions or immunosuppressants so you should always talk with your doctor before taking CBD.
6. Sleep disorders
CBD (short for cannabidiol) is one of over 200 chemical compounds known as cannabinoids that are found in cannabis. It is the second most prevalent active compound found in cannabis, behind THC (tetrahydrocannabinol), which is the compound in cannabis that has psychoactive properties and gives people a high. 2
31% of people taking CBD for other conditions such as anxiety or non-cancer-related pain reported improved sleep with CBD. 8
In a large case series of 72 people, 48 patients (66.7%) reported an improvement in sleep scores within the first month, but these fluctuated over time. 9
Unlike THC, CBD has no psychoactive properties and will not give you a “high”. There is no evidence it has any abuse or dependence potential and to date, there is no evidence that it is associated with any serious side effects, according to the World Health Organization.
In June 2018, the FDA approved Epidiolex (a plant-based formulation of CBD) to treat seizures for people 2 years of age and older with Dravet syndrome and Lennox-Gastaut syndrome (LGS), which are two rare forms of epilepsy.
A systematic review looking at the use of CBD for epilepsy concluded that there is insufficient evidence to support the efficacy and long-term safety of using it to treat epilepsy. It does, however, suggest, albeit in very low numbers, that small daily doses were safe in a small group of adults for a short period of time.
This article was reviewed on 4th December 2019.
Is CBD oil legal in the UK?
Supporters of CBD oil believe it may help a number of clinical conditions, including refractory epilepsy, chronic pain, depression, anxiety and acne. However, further robust evidence is required as much of the research is carried out on animal models.
This is particularly important if you are experiencing any concerning symptoms, if you have any pre-existing conditions or if you are taking any medication including statins, blood thinning medication and calcium channel blockers.
Early evidence looking into the use of CBD in the treatment of anxiety and depression has found some exciting results – although on very small samples. The first study assessed anxiety links with public speaking; it found a very specific dose of CBD (300mg) showed anti-anxiety effects. The second study was a stand-alone case report of one child with post-traumatic stress disorder (PTSD). It found CBD oil helped the child safely reduce her anxiety and improve sleep.
In a small 2018 study in the Journal of Alternative and Complementary Medicine, 11 people with post-traumatic stress disorder (PTSD) received CBD along with routine psychiatric care for eight weeks in an outpatient psychiatric clinic. Ten of the 11 experienced a decrease in their PTSD symptoms. CBD was generally well tolerated, the researchers write.
Several preclinical studies suggest CBD can produce beneficial effects against Parkinson’s disease, Alzheimer’s disease and multiple sclerosis. Huntington’s disease and cerebral ischemia were also tested, although significant positive results were not recorded. Further clinical studies are needed to confirm CBD’s benefits when used as a treatment for these disorders.
3. Reduce PTSD Symptoms
Three well-vetted studies provide the basis of support for the FDA’s decision. In these trials, 516 patients with Lennox-Gastaut syndrome or Dravet syndrome received either Epidiolex or a placebo. Epidiolex, when taken along with other prescribed medications, decreased the frequency of participants’ seizures compared to the placebo.
Meanwhile, continued studies in the U.S. indicate CBD is effective in treating chronic, non-cancer pain. In one 2020 study, researchers administered CBD topically to a group of patients with symptomatic peripheral neuropathy (a result of brain nerve and spinal cord nerve damage) while another group with the same condition received a placebo. Results showed a significant reduction in intense, sharp pains and cold, itchy sensations in those who used the topical CBD compared to those who used the placebo. No participants reported adverse side effects.
In one such study, researchers administered CBD to people with heroin use disorder. Over the course of a week, CBD significantly reduced heroin users’ cue-induced cravings, withdrawal anxiety, resting heart rate and salivary cortisol levels. No serious adverse effects were found.