“If you take pure CBD, it’s pretty safe,” said Marcel Bonn-Miller, an adjunct assistant professor at the University of Pennsylvania’s Perelman School of Medicine. Side effects in the Epidiolex trial included diarrhea, sleepiness, fatigue, weakness, rash, decreased appetite and elevated liver enzymes. Also, the safe amount to consume in a day, or at all during pregnancy, is still not known.
Up in the wee hours of the night, stuck watching videos of puppies? CBD may be promising as a sleep aid; one of the side effects of the Epidiolex trials for epilepsy was drowsiness, according to Mr. MacKillop, a co-author of a review on cannabinoids and sleep. “If you are looking for new treatments for sleep, that may be a clue,” he said.
But he cautions that the side effects could have been because of an interaction with other medications the children were taking to control the seizures. So far, there hasn’t been a randomized, placebo-controlled, double-blind trial (the gold standard) on sleep disorders and CBD.
Does CBD help sleep and depression?
Some CBD products may contain unwanted surprises. Forensic toxicologists at Virginia Commonwealth University examined nine e-liquids advertised as being 100 percent natural CBD extracts. They found one with dextromethorphan, or DXM, used in over-the counter cough medications and considered addictive when abused; and four with a synthetic cannabinoid, sometimes called Spice, that can cause anxiety, psychosis, tachycardia and death, according to a study last year in Forensic Science International.
Recently, the F.D.A. sent a warning letter to Curaleaf Inc. about its “unsubstantiated claims” that the plant extract treats a variety of conditions from pet anxiety and depression to cancer and opioid withdrawal. (In a statement, the company said that some of the products in question had been discontinued and that it was working with the F.D.A.)
More than 60 percent of CBD users were taking it for anxiety, according to a survey of 5,000 people. Does it help?
take your money?
American Council on Science and Health: “CBD And THC – The Only Difference Is One Chemical Bond.”
As part of the Farm Bill in December 2018, Congress legalized hemp. But there are still rules about where and how you can sell products that contain CBD. You can’t sell some across state lines, for example. All CBD products are illegal if they’re sold with the promise of medical benefits.
Check your state’s laws before buying products with CBD or THC.
U.S. National Library of Medicine ClinicalTrials.gov: “CBD.”
Harvard Health Publishing: “Answers to the top questions about cannabis extract,” “Medical marijuana.”
You’re probably hearing a lot about cannabis and marijuana products as they become legal in more and more states. Two natural compounds are getting the most attention: CBD and THC.
CBD doesn’t cause that high. Instead, it’s thought to work with other elements in the body linked to feelings of well-being.
According to a 2012 study in the Journal of Experimental Medicine, rats injected with inflammatory chemicals in their hind feet experienced less inflammation and neuropathic pain when treated with an oral dose and spinal injection of CBD.
Remember, because CBD oils are largely unregulated, there is no guarantee that a product is either safe or effective.
For this study, nine healthy men took either 600 mg of CBD or the same dose of a placebo. According to the researcher, those treated with CBD had lower blood pressure before and after exposure to stressful stimuli (including exercise or extreme cold).
Human studies evaluating the use of CBD in treating chronic pain are lacking. Those that do exist almost invariably include THC, making it difficult to isolate CBD’s distinct effects.
Clinical research has shown that CBD oil can trigger side effects. Severity and type can vary from one person to the next.