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Among the few human trials evaluating CBD’s anxiolytic effects was one published in the Brazilian Journal of Psychiatry in 2019. For this study, 57 men were given either CBD oil or a placebo before a public-speaking event. Anxiety was evaluated using physiological measures (such as blood pressure, heart rate, etc.) and a relatively reliable test for mood states known as the Visual Analog Mood Scale (VAMS).

Scientists believe that CBD reduces nerve pain by binding to glycine receptors in the brain that regulate the speed at which nerve signals pass between nerve cells.

Addiction

Instead, CBD is thought to influence other receptors, including opioid receptors that regulate pain and glycine receptors involved in the regulation of the “feel-good” hormone and neurotransmitter serotonin.

Since some CBD oils contain trace amounts of THC, you should avoid driving or using heavy machinery when taking CBD oil, particularly when first starting treatment or using a new brand.

Cathy Wong is a nutritionist and wellness expert. Her work is regularly featured in media such as First For Women, Woman's World, and Natural Health.

“Touching the plant can very easily develop a dermatitis, itching, and skin reactions,” he said.

“You can have a cross-reaction with certain foods that share certain antigens, certain components, with the cannabis plant itself,” Silvers said.

While there isn’t much research supporting the idea that CBD oil can help the discomfort associated with common allergy symptoms, there is some research related to its general effects on inflammation, which is part of the body’s allergic reaction process.

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There’s not much in the way of allergy research specifically for CBD oil, but the cannabis plant itself has been linked to allergic reactions in some people. Photo by: Gina Coleman/Weedmaps

Such foods may include tomatoes and stone fruits containing pits such as peaches, he said. It’s a similar cross-reactivity to what is seen in people with ragweed allergies who might experience symptoms such as itchy mouth if they eat fruit in the melon family, he added.

Though there’s not much in the way of allergy research specifically for CBD oil at this point, the cannabis plant itself has been linked to allergic reactions.

Silvers said that the type of allergic reaction depends on the type of exposure. In addition to cannabis pollen allergies and food-based allergies, skin allergies are also a possibility.

Humans commonly experience allergic reactions to certain types of plant pollen. Since CBD originates from the cannabis plant, it’s easy to wonder whether you could be allergic to CBD, and more importantly, whether you should be concerned about it.

Potential side effects include dry mouth, dizziness, lethargy, nausea, diarrhea, and drowsiness. Generally speaking, these effects aren’t anything to be concerned about and are typically caused by using too much CBD at once or just having sensitivity to CBD.

Bad Reactions to CBD

If you’re wondering why anyone could be allergic to CBD, the short answer is histamines.

Bad reactions to CBD certainly aren’t common, but they are possible.

CBD products are becoming increasingly popular among people of all demographics regardless of gender, age, and even nationality. There has also been an increase in cases of people reporting adverse effects of CBD. Some of these symptoms are considered to be side effects or sensitivity to CBD, while other symptoms may be allergic reactions to CBD.