"To date, there is no evidence of public health related problems associated with the use of pure CBD."
Cannabis-extract CBD oil is typically legal in states that have also legalized recreational marijuana, however its status is usually complicated.
Dangerous Side Effects of CBD Oil
Nausea and gastrointestinal issues are a pretty common side effect of CBD oil. This can lead to vomiting, diarrhea, dizziness and other symptoms associated with a digestive problem (think how you would feel after eating something that disagreed with you). In part, some people simply don't digest CBD oil well. This is not uncommon with oils and supplements.
• It can make Parkinson's disease worse.
Cannabidiol is one of the two active ingredients in marijuana, but on its own is not enough to get you high. It can, though, help you feel better under the right circumstances.
Blood thinners are a common prescription for people with various medical conditions. And many people turn to CBD oil for relief of some symptoms from chronic medical conditions. While individuals may take these two substances for different reasons, you must be extremely cautious, since not all blood interacts positively with CBD.
Specifically, CBD may act as a potent competitive inhibitor for all the enzymes in the CYP450 system, which may cause Warfarin to stay in your bloodstream for too long since its breakdown is impaired. As such, taking CBD may increase Warfarin plasma concentration in your body, as well as the INR (time taken for your blood to clot). This could potentially cause bleeding complications.
Is It Safe to Use CBD and Blood Thinners Together?
Different enzyme systems metabolize different medications in your body. Specifically, most medications are metabolized by the cytochrome P-450 system, commonly known as the CYP450 system. This system of enzymes is found within your liver; it’s responsible for metabolizing and processing the chemicals that are contained in most medications. This system contains approximately 50 distinct enzymes that address your blood’s workings. The CYP450 system is essential when it comes to drug prescription and establishing the right dosages.
In a separate study, researchers used a cannabis extract to treat obese and lean lab rats. Results indicated that half of the clotting times recorded were two times greater than the control groups (rats that were not treated with the cannabis extract). These studies indicated that the cannabinoids CBD, THC, and CBN have an anticoagulant effect.
Other studies have also indicated that CBD oil affects anticoagulants and platelets by inhibiting their production, thereby increasing blood clotting times.
One of the main metabolic systems in the body is the cytochrome P-450 enzyme system , which is made up of liver enzymes that break down certain drugs in the body, with removal of potentially harmful byproducts. If the P-450 enzyme system is inhibited by a compound like CBD, medications typically broken down by the liver enzymes remain in the system for longer than desirable, making it more likely you will experience side effects from the medication.
Although CBD oil has been found to be generally well-tolerated and without any significant side effects in studies , it can interact negatively with some medications. Often referred to as the ‘grapefruit effect,’ CBD oil is one of a number of natural substances that can slow down systems the body uses to metabolize and break down toxins.
Interactions Between CBD and Blood Thinners
The effects of CBD oil on blood clotting are not well understood, but it is thought that a few factors may be involved. First is CBD oil’s impact on blood flow.
Both CBN and THC are present in full spectrum CBD oil, along with all the other cannabinoids and terpenes present in cannabis. CBD oil derived from the industrial or agricultural hemp variety of the cannabis plant contains less than 0.3% THC, which is in line with federal regulations.
If you’d rather not have any THC in your CBD product, but still want the anticoagulant effects of CBN and CBD, a broad spectrum CBD oil would be ideal. Broad-spectrum CBD products contain all the cannabinoids and terpenes of the hemp plant except THC. If you aren’t sure whether you’d like a full- or broad-spectrum product, a good place to start is researching your state’s laws on cannabis, THC, and CBD, as well as seeking advice from a medical professional.