More recent research points to THC being more effective at reducing nausea and vomiting than CBD.
Unlike THC, CBD has no psychoactive properties and will not give you a “high”. There is no evidence it has any abuse or dependence potential and to date, there is no evidence that it is associated with any serious side effects, according to the World Health Organization.
Conclusion: CBD may relieve anxiety before events such as public speaking but it is not known what the optimal dose is.
9. Nausea and vomiting
In June 2018, the FDA approved Epidiolex (a plant-based formulation of CBD) to treat seizures for people 2 years of age and older with Dravet syndrome and Lennox-Gastaut syndrome (LGS), which are two rare forms of epilepsy.
Conclusion: CBD is beneficial for treating certain types of epilepsy.
Animal studies have shown that CBD has a positive effect on serotonin levels in the brain, and serotonin. Low levels of serotonin are thought to play a key role in mood as well as pain. 11
Anxiety scores decreased in a large case series of 72 patients, with 57 patients (79.2%) reporting decreased scores within the first month after CBD treatment. 9
Research suggests people with ALS can benefit from the entourage effect created by the combination of THC and CBD, similar to people with PTSD. In a 2019 study, patients received a combination of THC and CBD in varying doses depending on their needs and preferences. Those with mild, moderate or severe spasticity (muscle tightness and stiffness) due to ALS reported high levels of satisfaction with the treatment, and those with moderate to severe spasticity reported higher satisfaction rates than those with mild spasticity.
Some studies—both preclinical animal and human clinical trials—suggest CBD could be used to help treat people who are dependent on opioids.
Four other human trials from 2012 to 2016 suggest CBD reduces PTSD symptoms, although some include THC, or tetrahydrocannabinol, the main mind-altering element in cannabis. When THC and CBD work together, they create what’s called an “entourage effect,” complementing each other’s benefits and potency. For example, taking the same dose of THC and CBD together tempers the “high” from THC, while just a little THC paired with more CBD enhances the effects of the CBD.
6. Relieve Unmanageable Pain
Preclinical and clinical studies show that CBD has antioxidant and anti-inflammatory properties. Researchers deduce these characteristics can provide significant neuroprotection, or protection against numerous pathological disorders.
Cannabidiol, or CBD, is a chemical compound found in the cannabis sativa plant. When applied topically or consumed through smoke inhalation or edible consumption, CBD interacts with neuroreceptors in your endocannabinoid system, which sends signals between your cells to help regulate your movement, mood, homeostasis and immune system.
When introduced topically, CBD oil doesn’t affect the systemic issue as it might if it were introduced directly into the bloodstream. Instead, topical CBD is more localized and treats pain in a certain area. Since it’s more direct, it may have a more pronounced effect.
Margaret Rajnic, a doctor of nursing practice experienced in medical cannabis and CBD, emphasizes the importance of using therapy in tandem with any type of cannabis or CBD for PTSD. “There is an amount of therapy that is needed for PTSD,” she says. “But CBD will give you that little bit of decreased anxiety.”
For all the above uses of CBD, more human studies are needed to draw conclusive results.
One study reported reduced pain and muscle spasms in people with multiple sclerosis.
Early evidence looking into the use of CBD in the treatment of anxiety and depression has found some exciting results – although on very small samples. The first study assessed anxiety links with public speaking; it found a very specific dose of CBD (300mg) showed anti-anxiety effects. The second study was a stand-alone case report of one child with post-traumatic stress disorder (PTSD). It found CBD oil helped the child safely reduce her anxiety and improve sleep.
What is CBD oil used for?
This article was reviewed on 4th December 2019.
What is CBD oil, is it legal in the UK and what are the benefits and risks of using it? We asked a dietitian to take a closer look at this food supplement.
Although the use of CBD is controversial, it does seem to be tolerated by most people. It has, however, caused hypotension and light-headedness in a small number of patients. As it does not contain the THC part of the cannabis plant, the oil will not induce a ‘high’.
There are some suggestions from animal studies that CBD may be beneficial for osteoarthritis, through topical application for inflammation or joint pain.