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A key study [10] published in the American Diabetes Association Journal in 2016, noted that CBD had little to no effect on glycemic control. The study did find that THCV, a cannabinoid found in hemp, significantly decreased fasting blood glucose and improved pancreatic beta-cell function for those with diabetes. While CBD had no significant effect on blood sugar levels, it did decrease circulating levels of resistin, a hormone associated with obesity and insulin resistance.

While CBD is shown to be relatively safe, it is always pertinent to discuss use of a dietary supplement such as CBD with a medical provider such as your doctor or pharmacist. CBD has been shown to interact with some commonly used medications, the result of this could be minor or severe. This is why it is important to discuss this with your healthcare provider first before using CBD. It helps possibly prevent any adverse effects or interactions from the use of CBD oil for diabetes or other dietary supplements.

The strongest evidence we have and have seen with CBD is its role as an anti-inflammatory agent [8] with its effects on Arachidonic acid (AA) production and release as well as cytokine release both of which are key pathways in inflammatory signaling. This research area has been building an array of research and have had many interesting reports in possible therapeutic applications towards many diseases. However in general, CBD and its effects on inflammation in diabetes has not been studied extensively in many people. It’s worth noting however, that chronic inflammation plays a key role in developing insulin resistance which is often a trigger for type 2 diabetes.

Cannabinoids are the derivatives of the cannabis plant, the most potent bioactive component of which is tetrahydrocannabinol (THC). The most commonly used drugs containing cannabinoids are marijuana, hashish, and hashish oil. These compounds exert their effects via interaction with the cannabinoid receptors CB1 and CB2. Type 1 receptors (CB1) are localised mostly in the central nervous system and in the adipose tissue and many visceral organs, including most endocrine organs. Type 2 cannabinoid receptors (CB2) are positioned in the peripheral nervous system (peripheral nerve endings) and on the surface of the immune system cells. Recently, more and more attention has been paid to the role that endogenous ligands play for these receptors, as well as to the role of the receptors themselves. So far, endogenous cannabinoids have been confirmed to participate in the regulation of food intake and energy homeostasis of the body, and have a significant impact on the endocrine system, including the activity of the pituitary gland, adrenal cortex, thyroid gland, pancreas, and gonads. Interrelations between the endocannabinoid system and the activity of the endocrine system may be a therapeutic target for a number of drugs that have been proved effective in the treatment of infertility, obesity, diabetes, and even prevention of diseases associated with the cardiovascular system.

Keywords: CB1 receptor; cannabinoid system; endocannabinoids; endocrine system.