Interestingly, slowing down the cytochrome P450 system is not just a result of CBD. Other substances that people consume every day like grapefruit, watercress, St. John’s Wort, and goldenseal can also have an inhibitory effect the system’s drug metabolism.
For this reason, it is important to consult your doctor if you are currently taking prescription drugs and are also interested in trying CBD. Although CBD itself isn’t known to produce any harmful side effects, it is possible that when mixed with certain drugs it might produce unwanted or unexpected reactions.
We believe that asking your physician questions about whether or not you can decrease a pharmaceutical medication while on CBD is something that will help move the industry and healthcare forward.
You may be asking yourself the question, “why and how does CBD interact with my prescription drugs?” The answer, in large part, lies with the cytochrome P-450 (or CYP450) system. Found within your liver, this system of enzymes is responsible for processing and metabolizing toxic chemicals in your body, including about half of the prescription drugs you might consume. In total, it is estimated that the CYP450 system contains about 50 different enzymes that essentially help to clean your blood.
The simple answer is that yes, CBD can have interactions with drugs, including blood thinners, that change the way those drugs affect your body. More specifically, the way that CBD is metabolized by your body can interfere with how your body normally metabolizes other drugs you take. This can then lead to those drugs hanging around and staying in your system longer than you want, which can alter the amount of the drug you need to take. This might then produce negative side effects or complications.
As you take CBD oil, one of the side effects is it can increase the quantity of coumadin, which is known to thin your blood. Coumadin, also known as Warfarin Sodium, is an anticoagulant, which means it thins the blood and extends the time it takes to clot the blood. As you can imagine, there are many medical reasons why this might be wanted.
Considering all of these factors, this is why it is even more important that the brands are held to account and deliver the quantities they state on the pack. As it stands, they are registered as food supplements rather than medicine, meaning the regulations are more relaxed, so you should read up on the third party lab test results and only opt for reputable brands. Ignore anything which is being produced in China, I promise you that!
The same effects have been seen when taking CBD oil, therefore if you are taking any of these medications then it might not be recommendable to have CBD oil.
Just the same, you might want to consider this if you are having any work done or an operation. It might help to calm your nerves, but the doctor will have to know about this and will most likely to tell you not to take any in the days leading up to this, but once again, you should speak to a medical professional beforehand.
A question that has been messaged to me multiple times over the past month, I wanted to cover off whether CBD thins your blood, how different products might affect this and why this is important for you.
2 mg/ml for THC . This means that CBD has a greater effect on your body’s clotting system than THC does.
Different enzyme systems metabolize different medications in your body. Specifically, most medications are metabolized by the cytochrome P-450 system, commonly known as the CYP450 system. This system of enzymes is found within your liver; it’s responsible for metabolizing and processing the chemicals that are contained in most medications. This system contains approximately 50 distinct enzymes that address your blood’s workings. The CYP450 system is essential when it comes to drug prescription and establishing the right dosages.
Anticoagulant Effects of CBD
Blood thinners are medications, taken orally or intravenously, to prevent blood clots from forming. Clots can block the flow of blood to your heart, brain, and lungs. While blood clotting is a vital process in your body, too much clotting can trigger potentially dangerous complications.
CBD products can be taken in several ways. CBD oil can be taken through sublingual administration (placing under the tongue), vaping, or capsules. Your doctor will help you evaluate the various forms of CBD administration and establish one that is likely to cause the least effect when combined with blood thinners.
Other studies have also indicated that CBD oil affects anticoagulants and platelets by inhibiting their production, thereby increasing blood clotting times.