Our natural endocannabinoids function on demand, meaning that when our body senses inflammation, or needs to return to homeostasis (a state of stable balance) it will release endocannabinoids that bind to cannabinoid receptors.
8. Atalay S, Jarocka-Karpowicz I, Skrzydlewska E. Antioxidative and Anti-Inflammatory Properties of Cannabidiol. Antioxidants. 2020;9(1):21.
Your Body Chemistry Matters
Keep in mind that while CBD can have many benefits, it is not a cure-all and should not be viewed as an alternative to your other pain care treatments. Rather, CBD should be considered a complementary treatment to add to your pain management toolbox.
CBD itself does not bind to receptors but is thought to work by inducing other components of the cannabinoid system.
The entourage effect also accounts for the terpenes 13 that can differ between various strains of marijuana and contribute to the plant’s effect. Some recent research points to the beneficial effects of this compound (think aromatherapy).
Many plants contain cannabinoids, and people often confuse CBD with THC (tetrahydrocannabinol) which is another type of cannabinoid. Unlike THC, CBD does not cause a “high” or euphoric effect because it does not affect the same receptors as THC.
An extensive 2018 review on the use of cannabis and cannabidiol products for pain relief stated:
By law, industrial hemp from which CBD is extracted must contain no more than 0.3 percent THC to be considered hemp, otherwise, growers are at risk of prosecution under federal law.
CBD (cannabidiol) is a compound that is usually extracted from industrial hemp.
CBD has been credited with relieving anxiety, inflammation, insomnia, and pain, although currently, the most scientific proof rests with its effects in people with epilepsy. Epidiolex is a prescription CBD oil that was FDA approved in June 2018 for two rare and severe forms of epilepsy, Lennox-Gastaut syndrome (LGS) and Dravet syndrome.
Another study, published in the European Journal of Pain in 2016, found that topical CBD gel significantly reduced joint swelling and measures of pain and inflammation in rats with arthritis.
While very few clinical trials have explored the pain-relieving effects of CBD oil, a report published in the Cochrane Database of Systematic Reviews in 2018 examined the use of a variety of cannabis-based medicines and found they might be of some benefit in the treatment of chronic neuropathic pain.
As more and more states across the U.S. legalize the use of marijuana, CBD oil has become more widely available. CBD oil is now sold in a range of forms, including capsules, creams, tinctures, and under-the-tongue sprays.
Lana Butner, ND, LAc, is a board-certified naturopathic doctor and licensed acupuncturist in private practice in New York City .
In studies using varied doses, routes of administration, and combination or whole products with THC, a number of side effects have been reported. These include anxiety, changes in appetite and mood, diarrhea, dizziness, drowsiness, dry mouth, low blood pressure, mental confusion, nausea, and vomiting.