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When shopping for the best CBD product, it’s important to do your research. While CBD use is generally regarded as safe, the purity and potency of different products may differ. Determine whether the product is made with full or broad-spectrum CBD (especially if you’re worried about drug testing) and choose products that have been third-party lab tested. Full-spectrum may have a tiny amount of THC whereas broad-spectrum is THC-free.
One of the most common side effects of CBD oil is weight changes and another is changes in appetite. Studies have shown both weight gain and weight loss correlated with CBD use, so more research is needed to make strong conclusions.
Why is it better?
Research suggests that CBD can safely be used in dietary supplements. It has been established that CBD contains negligible amounts of THC, the psychoactive component of cannabis, and that it is non-psychoactive and does not cause a “high” in users. Further, CBD does not have the potential for abuse or addiction. The World Health Organization (WHO) Expert Committee on Drug Dependence recommended not scheduling CBD within the International Drug Control Conventions. WHO cited the fact that there are no case reports of CBD abuse or dependence; no public health problems have been associated with CBD use; CBD has been found to be generally well tolerated with a good safety profile; and that there is no evidence that CBD is liable to be abused.1 Furthermore, the U.S. Health and Human Services Department (HHS) conducted a scientific review on CBD and concluded that it does not present a significant risk to the public health. HHS found that there is no evidence for classic drug withdrawal, no evidence that CBD causes physical or psychic dependence and no potential for abuse under the CSA 2 .
Exploring a legal path to market for food, beverages and dietary supplements containing CBD is consistent with FDA’s strong public health goals. Recognizing CBD products as lawful foods, beverages or dietary supplements would allow the agency to impose a reasonable regulatory framework around the processing, manufacturing and marketing of CBD products not intended for use as drugs. It would also permit the agency to enforce existing regulations regarding registration of manufacturing facilities; observance of good manufacturing practice regulations; supply chain security; compliance with food additive and new dietary ingredient provisions for food and dietary supplements; and post-market surveillance of serious adverse events. If FDA fails to act, consumer interest in CBD will continue to grow along with a thriving but plainly unlawful array of CBD products. No one benefits from a “wild west” scenario in which companies willing to risk FDA enforcement distribute these products without appropriate FDA oversight and guidance.
Is CBD safe?
Yes. The FDCA allows the HHS Secretary to create a regulation permitting the use of an ingredient in food and dietary supplements, despite a determination that it was first subject to clinical drug investigations as described above. This alternative would allow FDA to clearly establish a legal pathway to market for CBD as a food and dietary supplement. FDA Commissioner Dr. Scott Gottlieb raised the possible use of this authority in a December 20, 2018 statement on CBD following the passage of the Farm Bill. Clearly, FDA is open to and exploring this pathway 4 .
Cannabidiol (CBD) is a compound extracted from hemp or marijuana. The Agriculture Improvement Act of 2018 (Farm Bill) excluded hemp and its constituents from the definition of marijuana and removed it from the Controlled Substances Act (CSA). Hemp is a valuable agricultural commodity and contains only trace levels of tetrahydrocannabinol (THC), the intoxicating compound in marijuana. Hemp has been cultivated throughout human history for many purposes, including food, fiber and oil. Modern science has demonstrated that, in addition to its value as a food and fiber, hemp extracts naturally contain CBD and that CBD may have its own health-promoting benefits. Now, by excluding hemp from the definition of marijuana, hemp with no more than 0.3 percent THC (and its constituents such as CBD) is no longer a controlled substance under the CSA.
CBD’s prior status as a Schedule I controlled substance presented significant barriers to clinical research. However, in the past few years, changes to state and federal laws have removed some of the obstacles to conducting research. Scientists and physicians have demonstrated that CBD may have multiple benefits throughout the body. Emerging research shows that CBD interacts with cellular receptors in physiological processes that influence sleep, mood, and appetite without intoxicating effects.
The reactions between CBD oil, Ginkgo biloba, and Vitamin D likely have to do with their use of the cytochrome P-450 enzyme system, which is just a fancy name for the enzymes in your liver that help digest toxins and certain medications.
The reason for this interaction is discussed later in the article (see “Effects of CBD on Dietary Supplements”), and relates to the cumulative sleep-inducing properties of both supplements when used together. If St John’s Wort makes you feel drowsy, combining it with CBD oil may increase this effect. However, if it does not have this effect on you, or if sleep is desired, then the combination is of no concern.
St John’s Wort can also affect your serotonin levels in a similar way to antidepressants. CBD oil also increases the serotonin available to the body, so you are at increased risk of experiencing side effects related to high serotonin levels like nausea and dizziness.
Side Effects of CBD and Dietary Supplements
Here’s a chart breaking down the different delivery methods so you can decide what’s best for your needs and lifestyle.
Excess levels of iron within the brain have been linked to neurodegenerative diseases such as Alzheimer’s and Parkinson’s. A study on an animal test group found that the cognitive decline brought on by iron build-up could be reversed through the use of CBD.
As an anti-inflammatory, CBD oil can reduce the cause of joint pain at the source. An animal study on the use of CBD for joint pain found that CBD “significantly reduced joint swelling” and that it had “therapeutic potential for relief of arthritis pain-related behaviors and inflammation without evident side-effects.” For more information about CBD oil and joint pain, check out our CBD guide for people with rheumatoid arthritis.
If you’re thinking about adding CBD oil to your dietary supplement routine to help with insomnia, this cumulative effect could be seen as a positive. However, if sleepiness is not desired, the combination should be avoided.