Animal studies showed that topical CBD applications relieve pain and inflammation associated with arthritis with few side effects. The topical application of CBD is beneficial because CBD is poorly absorbed when taken by mouth and can cause gastrointestinal side effects. 6
CBD can interact with other medications used for epilepsy and some serious side effects have been reported, notably, a decrease in liver function when given to people already taking valproate.
Conclusion: CBD shows promise for improving the quality of life in people with Parkinson’s disease but larger trials are needed.
Animal studies have shown that CBD has a positive effect on serotonin levels in the brain, and serotonin. Low levels of serotonin are thought to play a key role in mood as well as pain. 11
An observational study of CBD treatment reported an improvement in self-reported quality of life measures for people with non-cancer-related pain but there was no statistically significant improvement in those with cancer-related pain or with neurological symptoms. 8
Other studies find CBD helpful in reducing various psychiatric and medical symptoms like anxiety, insomnia and pain in patients with substance use disorders, indicating that CBD may be an effective treatment for opioid addiction. However, further studies are necessary.
Three well-vetted studies provide the basis of support for the FDA’s decision. In these trials, 516 patients with Lennox-Gastaut syndrome or Dravet syndrome received either Epidiolex or a placebo. Epidiolex, when taken along with other prescribed medications, decreased the frequency of participants’ seizures compared to the placebo.
5. Alleviate ALS Symptoms
Arthritis involves the deterioration of the tissues in and around your joints. There are several types of arthritis, and symptoms include pain, stiffness and loss of motion. Arthritis treatment usually targets pain relief and improved joint function.
Some studies—both preclinical animal and human clinical trials—suggest CBD could be used to help treat people who are dependent on opioids.
Margaret Rajnic, a doctor of nursing practice experienced in medical cannabis and CBD, emphasizes the importance of using therapy in tandem with any type of cannabis or CBD for PTSD. “There is an amount of therapy that is needed for PTSD,” she says. “But CBD will give you that little bit of decreased anxiety.”
The Journal Neurotoxicology published another study  in their September 2015 edition that found that CBD also inhibits glutamate levels in the spinal cord and brain. Glutamate is associated with transmission and increased sensations of pain.
The British Journal of Pharmacology published a 2014 study  that found that the analgesic properties of CBD are mediated by the TRPV1 receptor, hence concluding that CBD could be used as a pharmacological alternative in treated chronic pain related to certain diseases.
1.1 Potential for Helping Fibromyalgia
In 2006, a study on lab rats showed that CBD lowered the incidence of diabetes  on its own. According to research, CBD can help benefit weight loss by boosting your body to convert white fat into eight-reducing brown fat, which in turn promotes noatherogenesisrmal insulin production as well as sugar metabolism.
Hence, CBD has an anti-inflammatory effect because when Cannabinoids engage with the Endocannabinoid system present in most organs throughout the body, inflammation is reduced systematically. Seeing as inflammation is involved in many diseases, the therapeutic potential of CBD is impressively wide-ranging.
JCJ Insight published a small study in 2017  , where researchers observed that CBD oil could help prevent blood-pressure fluctuations caused by stress. Recent research has also linked CBD with more benefits for the heart as well as the circulatory system, and the ability to lower high blood pressure.