High doses of CBD lowered blood pressure in a small trial on 9 people. In turn, THC seems to have a more complex effect: it slightly raises blood pressure in people lying down but increases the risk of sudden blood pressure drops when standing up [24, 25+].
You can reduce the risk of digestive issues by choosing forms that bypass the gut and directly release CBD into your bloodstream such as vapes, mouth sprays, and oil tinctures. High-quality oils without additives may also irritate your bowels less.
7) Immune Suppression
While rapid-release forms (mouth sprays and oil tinctures) deliver CBD directly into your bloodstream, slow-release forms (capsules, edibles, and teas) have to pass your digestive system first. This means their ingredients may irritate your bowels and give you nausea and diarrhea [76+, 77].
CBD oil is believed to be generally safe and well-tolerated, but it is not free of side effects. Read on to learn which adverse effects you should watch out for when using CBD oil, how the delivery form influences them, and what you can do to reduce your risk.
Vaping is considered safer than smoking cigarettes or joints because the oil is heated at lower temperatures that produce fewer toxic byproducts [76+ 79].
The endocannabinoid system consists of cannabinoid receptors that are located throughout the entire human body, including the brain. Cannabinoids in marijuana can activate these receptors, where they cause all sorts of reactions and processes. This is how the high from marijuana comes about, but the interaction with these cannabinoid receptors can affect many more bodily processes, with saliva production one of them.
If you want to really make sure you don’t run into dry mouth, you should make a point to limit your sugar and salt intake on a regular basis, even when you’re not smoking.
The Endocannabinoid System, Saliva & Cannabinoids
In the same way as chewing can be a good way to get some saliva flowing, you can lick a lollipop, take a cough drop, or some hard candy. Sucking on the candy or a lollipop has the same effect as chewing; it will increase saliva production to help you get rid of dry mouth.
Humans have enjoyed marijuana since ancient times, so “cotton mouth” isn’t exactly something new. But it was only recently, in 2006  , that this peculiar effect of weed has become the subject of scientific research, which is now helping us to understand it more.
In those cases where you think that chewing along or licking a lollipop doesn’t really help to get rid of a really nasty spell of dry mouth, you can look into demulcent cough drops. These oral demulcents are widely available over the counter. What they do is coat the mucous membranes with a moist film, which can prevent or help get rid of the dry cotton mouth feeling.
CBD—the abbreviation for cannabidiol, a substance that’s generally derived from the hemp plant—has skyrocketed in popularity over the last five years. In fact, according to some research, “CBD” as a Google search term remained stable from 2004 to 2014 but has since ballooned by up to 605%.
In some cases, those who ingest CBD supplements might experience nausea, says Dr. Matharu-Daley. This depends on how sensitive the person is to CBD, as well as the amount they ingest.
Can Interact With Other Medications
The most comment side effects of CBD include drowsiness, gastrointestinal issues, dry mouth, reduced appetite, nausea, and interaction with other medications. Those are outlined in detail below.
“If the CBD is from a reputable source and one that has been inspected by a third-party independent lab, the content of CBD is more reliable,” notes Dr. Matharu-Daley. “The CBD should be organically grown, free of pesticides and heavy metals, and not sourced in food which can affect absorption. Generally, CBD is safe and side effects are few at low doses.”
CBD is technically an unregulated substance in the United States and therefore it ought to be used with caution. This is especially important for those taking additional medications and/or those with ongoing medical issues. That said, preliminary research on CBD and its benefits are promising in relation to helping with mild to moderate health concerns and it is generally considered a safe substance. Health professionals do not consider CBD a cure-all for serious medical issues, including cancer.