Despite the fact that people in favor of using cannabidiol therapeutically say that it does have benefits, the U.S. government has done research that isn’t necessarily completely conclusive or in favor of these assertions, although there is some early evidence showing the use of CBD does have some benefits. The following information provides an overview of answers to the following questions:
People frequently wonder what is CBD or what is cannabidiol? Cannabidiol is also called CBD, so these two are the same thing, and they are a compound derived from cannabis that is said to have medical and therapeutic benefits. Proponents of CBD say that it can help deal with conditions including inflammation, chronic pain, psychosis, anxiety, and seizures among others.
What is Cannabidiol?
As touched on above, cannabidiol or CBD is derived from cannabis. The CBD is one of the most prevalent chemical compounds found in the cannabis plant, but it’s different from something called THC that’s also derived from CBD because it’s not psychoactive. People in favor of the use of CBD often say that it’s a way to get relaxation and therapeutic benefits without feeling high, but undoubtedly the compound does have effects on the person using it. Although it is one of the most numerous compounds found in the cannabis plant, CBD isn’t the only one, and there are different concentrations of CBD oil as well.
However, while the CB1 and CB2 receptors are activated by the use of cannabis with THC contents, CBD is different. CBD activates receptors such as the serotonin and adenosine receptors. Because of the receptors activated by CBD, using CBD hemp oil can change things like pain perception and inflammation. CBD also activates the adenosine receptors, which helps with anxiety because these receptors release dopamine. In some cases when people take higher concentrations of CBD it may activate the 5-HTIA receptor, which is a serotonin receptor, and this is why people feel CBD has an anti-depressant effect. Also important to understand when looking at how CBD works is the fact that when someone takes it, it blocks the psychoactive effects of THC, so people can take advantage of what some say are the benefits of CBD without the mind-altering effects of THC.
CB1 receptors are found primarily in the central nervous system, although also in smaller amounts throughout the body including in the liver and lungs. CB2 receptors, on the other hand, are part of the human immune system, and they’re found in certain blood cells. CB1 receptors are part of how the body and the central nervous system produces and releases certain neurotransmitters, which is why there are psychoactive effects of using certain types of cannabis. The CB1 receptors also deal with various processes in the liver, and they can impact things such as pleasure, appetite, and tolerance for pain. As was touched on, CB2 receptors interact with the immune system.
CBD has been touted for a wide variety of health issues, but the strongest scientific evidence is for its effectiveness in treating some of the cruelest childhood epilepsy syndromes, such as Dravet syndrome and Lennox-Gastaut syndrome (LGS), which typically don’t respond to antiseizure medications. In numerous studies, CBD was able to reduce the number of seizures, and, in some cases, it was able to stop them altogether. Videos of the effects of CBD on these children and their seizures are readily available on the Internet for viewing, and they are quite striking. Recently the FDA approved the first ever cannabis-derived medicine for these conditions, Epidiolex, which contains CBD.
Side effects of CBD include nausea, fatigue and irritability. CBD can increase the level in your blood of the blood thinner coumadin, and it can raise levels of certain other medications in your blood by the exact same mechanism that grapefruit juice does. A significant safety concern with CBD is that it is primarily marketed and sold as a supplement, not a medication. Currently, the FDA does not regulate the safety and purity of dietary supplements. So, you cannot know for sure that the product you buy has active ingredients at the dose listed on the label. In addition, the product may contain other (unknown) elements. We also don’t know the most effective therapeutic dose of CBD for any particular medical condition.
Is cannabidiol legal?
CBD is commonly used to address anxiety, and for patients who suffer through the misery of insomnia, studies suggest that CBD may help with both falling asleep and staying asleep.
Some CBD manufacturers have come under government scrutiny for wild, indefensible claims, such that CBD is a cure-all for cancer, which it is not. We need more research but CBD may be prove to be an option for managing anxiety, insomnia, and chronic pain. Without sufficient high-quality evidence in human studies we can’t pinpoint effective doses, and because CBD is currently is mostly available as an unregulated supplement, it’s difficult to know exactly what you are getting. If you decide to try CBD, talk with your doctor — if for no other reason than to make sure it won’t affect other medications you are taking.
Cannabidiol (CBD) has been recently covered in the media, and you may have even seen it as an add-in booster to your post-workout smoothie or morning coffee. What exactly is CBD? Why is it suddenly so popular?
“It's unlikely that this is the first case in 5,000 years of a cannabinoid causing Stevens-Johnson Syndrome (SJS), but it is certainly possible,” he said.
The case report notes that the “new liposomal CBD extract spray” came from Natural Native, a CBD company based in Oklahoma. Last November, the company received a warning letter from the Food and Drug Administration. On Facebook and on its website, Natural Native broke several FDA rules for marketing CBD water, marketing CBD products intended for infants and otherwise making scientific claims that suggested CBD was a drug that could help with health conditions ranging from acne to chronic pain to cancer. (CBD is a “drug” in the taxonomical sense, but in the legal sense, a drug needs FDA approval to be marketed as such.)
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Other researchers similarly pointed to gaps in the knowledge.
“He should take that assertive assumption out of the title,” Bannister said. “Even turning it into a question. It would be that simple.”
Angry red lesions broke out over 30 percent of her body, including her eyes and groin. Skin peeled from her arms and back. Doctors administered more antibiotics, more anti-inflammatory steroids. They didn’t work. After a month of suffering, she was dead from septic shock, the final result of a rare and extremely serious allergic reaction called Stevens-Johnson Syndrome (SJS), according to an account published February in Case Reports in Ophthalmological Medicine.