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cbd oil and sibo

PHOEBE: What happens there? How does it help that permeability?

PHOEBE: Very cool. Awesome. I can’t wait for everyone at home to experiment with Radical Roots and all the other fantastic resources you’ve mentioned. I will, of course, link to everything in the show notes. Thank you so much, Chloe, for coming on today. Is there anything else you’d like to add about gut health and this incredible plant medicine that we haven’t covered yet?

A quick taste of what we’ll cover:

CHLOE: CBD potentiates this one specific bacteria to help with MS, which I thought was super interesting because I had just read a research study about the keto diet potentiating the same bacteria in order to help with epilepsy, so I was super stoked on that. Yeah, CBD helps balance microbiome and helps reduce inflammation in the gut, and it helps strongly with the tight junctions so that it helps prevent leaky gut syndrome.

PHOEBE: Very cool. I assume that Radical Roots does an oil. Let’s talk, just for a second, about, I guess – I don’t know what you call it – method of delivery. What are the different benefits between just an oil under the tongue, chocolate or gummies, or miscellaneous edibles, and then smoking?

PHOEBE: Yeah, I feel like it’s everywhere. Besides your own Radical Roots, which I will of course link to in this and Charlotte’s Web, which you mentioned before, do you have any other favorites that you would recommend in the good guy posse of products out there?

While most would assume this study only shows the immune suppression activities of phytocannabinoids, this study found that a change in microbiota within the gut and lungs is what leads to the halting of cytokine storms.

“We have a mouse model of ARDS where we inject bacterial toxins into the mice, and they die within four to five days because of cytokine storms. We found if you give THC, it cures the mice. They are just running around and healthy. That was amazing.”

At Potter, we test all our products at ProVerde Labs, an accredited third-party cannabis testing facilitly in Millford, Massachusetts. You can easily access the the lab report for each Potter product by batch number here , or by simply scanning the QR code located on our product labels. Recent studies have shown that up to 1500mg of CBD is generally well tolerated in humans. Side effects tend to be mild compared to traditional pharmaceuticals and may include appetite suppression, diarrhea, and fatigue.


In this study, researchers at the University of Naples Federico II found that CBG showed an ability to regulate GI motility in animal studies of mice afflicted with chemically induced hypermotility. Additionally, CBG showed a curative and protective mechanism for Colitis within the GI tract.

In this study Dr. Ethan Russo explains the important role of the endocannabinoid system (ECS) for gut health. We learn that the Endocannabinoid System regulates GI propulsion, secretion and gut inflammation.

Dr. Russo references a previous study from 2004 which found that the Endocannabinoid system contained a powerful pain blocking mechanism which was able to mitigate the pain response in IBS sufferers:

Our Select Spectrum line utilizes full spectrum CBD and consistent terpene profiles along with beneficial cannabinoids like CBG (cannabigerol) at a consistent ratio of CBD to CBG. The high concentration of additional cannabinoids like CBG, CBC, or CBN contribute to a powerful entourage effect, designed for specific wellness needs.

I found out on two vacations in states where it is legal that higher THC edibles helped my symptoms (SIBO-D), so when I got back I tried CBD for a few weeks. Nope, did nothing for me, and that was several weeks of continuous CBD treatment in comparison to just a few isolated THC administrations, which were very quickly efficacious. My SIBO has responded extremely well to rifaximin and identification of triggers through a low FODMAP diet.

One issue with CBD is that it might slow down motility. Which is what is believed to cause SIBO

The overall absorption rate for inhaled CBD inhaled is 7% ingested it's only around 5%. Given that the rates are so low it's important to boost them anyway you can.

I live and die by CBD. Here are some pointers:

Has anyone tried CBD for leaky gut & pain?

I am not into this stuff at all, but considering trying if I can get quality, low THC stuff.

CBD and THC are synergistic meaning they are best absorbed when taken together. If you have safe access I would suggest getting something with small amounts of THC if you tolerate it. I do not tolerate THC but my pen is 2% THC 98% CBD. This is a below threshold dose of THC so it works better but I never get high.