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cbd oil and lymphoma

In general, medical marijuana patients prefer the magical green herb to other pain control medications. Prescription pain medication can have its own debilitating side effects like intoxication and addiction. A significant amount of distress from pain is caused by anxiety about the pain. The classic high experienced when using cannabis can reduce anxiety and make the pain less psychologically agonising.

It is during deep sleep that the body and brain undergo regenerative [10] and restorative processes. Cannabis encourages deeper sleeps for longer periods. Getting good sleep is crucial to maintaining a healthy lymphatic and immune system. Decreased sleep is linked [11] to poor immune function, which must be avoided at all costs by lymphoma patients.

The compromised immune system also makes the patient vulnerable to infection, bacterial diseases, and viruses. When your body gets a cold or the flu, the symptoms you experience are your body’s battle with the pathogen flowing in your blood. All thanks to your immune system.

SANE IN THE BRAIN

Sleep is an indispensable part of anyone’s life, and is especially important when fighting disease or recuperating. The pain from lymphoma and chemotherapy can interfere with healthy sleep. Research has shown that cannabis helps patients fall asleep quicker, then sleep deeper and longer.

The types of symptoms can vary depending on where the lymphoma begins. Internal glands that swell can put pressure on the stomach and gut, inducing nausea. Masses that appear in the chest or armpits will metastasise to the nearest cluster of lymph glands and so on.

Antibodies are protein markers that the body uses to identify invading pathogens. When an invader is identified, the immune system goes to work to seek and destroy. The lymphatic system then drains the harmless waste away and the body continues along, oblivious and healthy.

Whether cannabis can be effective in the direct fight against Hodgkin’s lymphoma remains to be seen. However, it may be able to help the patient in a number [6] of other ways. Appropriate use of marijuana and its extracts can ease the symptoms of lymphoma and improve one’s overall quality of life.

Further biochemical analysis of glioma tumour tissues excised from nude mice treated in vivo with CBD indicated a significant decrease of activity and content of 5-LOX, as well as a marked stimulation of FAAH and a decrease of AEA content [42].

In the light of its safety records, these results suggest that CBD might be worthy of clinical consideration in colon cancer prevention.

CBD treatment concomitantly upregulated the tissue inhibitor of matrix metalloproteinases-1 (TIMP-1) and the CBD-elicited decrease in tumour cell invasiveness was reversed by knocking down TIMP-1 expression through a siRNA approach. These results suggest a causal link between TIMP-1 upregulation and CBD anti-invasive action. CBD was also shown to induce p38 and ERK phosphorylation as upstream mechanisms for TIMP-1 induction and subsequent decreased invasiveness. Interestingly all these cellular events were blocked by cannabinoids or TRPV1 receptor antagonists.

CBD and leukaemia/lymphoma

Four years later, the same group [32] demonstrated that the observed effect of CBD on Id-1 expression was mediated by the upregulation of the extracellular signal-regulated kinase phosphorylation (pERK). Indeed, the ERK inhibitor, U0126, partially reverted CBD-induced inhibition of proliferation and invasion as well as its effect on Id-1 expression. Besides ERK upregulation, also the production of reactive oxygen species (ROS) was shown to mediate CBD-induced effects on cell proliferation and Id-1 expression, since the use of a ROS scavenger (tocopherol) reversed the aforementioned CBD effects. Moreover, these authors demonstrated that CBD was effective in reducing the primary tumour mass and the size and number of metastatic foci in vivo.

Finally, the relationship between CBD-induced apoptosis and autophagic cell death was explored by blocking each form of cell death with specific inhibitors. Caspase inhibition reduced CBD-induced apoptosis and the expression of protein markers in breast cancer cells, whereas the inhibition of autophagy enhanced apoptosis as a compensatory/alternative mechanism of cell death. The apoptosis : autophagy ratio in CBD-induced cell death seemed to be mediated via Beclin1, a key signalling molecule in the autophagic process. CBD treatment induced the cleavage of Beclin1 and the subsequent translocation of the cleavage product to the mitochondria where it may induce apoptosis through the enhancement of cytochrome C release [34, 35].

Cannabinoids are currently used in cancer patients to palliate wasting, emesis and pain that often accompany cancer. A significant advancement in cannabinoid use in cancer treatment came from the discovery of a potential utility of these compounds for targeting and killing cancer cells. In 1975 Munson et al. [17] demonstrated that the administration of Δ 9 -THC, Δ 8 -THC and cannabinol inhibited the growth of Lewis lung adenocarcinoma cells in vitro as well as in vivo after oral administration in mice. The interest in anticarcinogenic properties of cannabinoids was even renewed after the discovery of the eCB system and the cloning of the specific cannabinoid receptors. Since then, several cannabinoids have been shown to exert anti-proliferative and pro-apoptotic effects in various cancer types (lung, glioma, thyroid, lymphoma, skin, pancreas, uterus, breast, prostate and colorectal carcinoma) both in vitro and in vivo[18–26]. Moreover, other antitumourigenic mechanisms of cannabinoids are currently emerging, showing their ability to interfere with tumour neovascularization, cancer cell migration, adhesion, invasion and metastasization [27].

It is worth noting that CBD decreased invasiveness in a range of therapeutically relevant concentrations (0.01 to 0.05 µ m ), since the peak plasma concentrations of CBD in healthy volunteers following administration of Sativex™ (1:1 ratio of Δ 9 -THC and CBD) was reported to be between 0.01 µ m to 0.05 µ m [54].

Cannabinoids like CBD tackle the source of lymphoma. When you take CBD, it blocks FAAH, a fatty acid that breaks the cannabinoid anandamide down. Our bodies create anandamide to manage functions like pain sensation and cell death. CBD increases the amount of anandamide in your body, improving its ability to kill unnecessary cells. It also modifies a range of other functions that contribute to cell death.

Since lymphoma manifests in so many ways, we recommend getting a doctor’s help with finding a CBD medication. Marijuana-trained physicians understand how CBD works with the body. They can help you figure out where to buy legal medicine and how to use it. Search our database of qualified doctors today to find one near you.

CBD may also have the ability to reduce nausea from lymphoma and cancer treatments. Certain cannabinoids seem to impact the area of the brain that controls nausea. However, researchers don’t know how they affect it. It looks like anandamide has no effect on nausea on its own, but other cannabinoids found in CBD medicine could help.

Boosting the Endocannabinoid System to Relieve Cancer Symptoms

Most patients receive chemotherapy or radiation treatment intended to kill cancer cells. You can also choose stem cell therapy or immunotherapy. CBD helps you manage your lymphoma symptoms and reduces treatment side effects.

Everyone has an endocannabinoid system (ECS) that manages different aspects of our bodies and consists of a network of cannabinoids and receptors. CB1 and CB2, the two types of receptors, attach to cannabinoids and influence bodily functions.

Lymphoma is a type of cancer that affects your lymph system. You may know about lymph nodes, but bone marrow and the spleen also count as part of the lymph system. Your lymph tissue creates white blood cells and protects your body from foreign invaders. When you have lymphoma, your lymph tissue has excess cells that spread and cause damage.

You can buy a variety of CBD medications in states with and without medical marijuana programs. Natural health stores and online shops sell CBD oil. If you buy a high-quality product, you can benefit from CBD’s healing properties. Dispensaries also sell CBD items in accordance with recreational and medical marijuana laws. Since cancer qualifies for cannabis medicine in numerous states, you may want to register for your state’s patient program.