Ischemia is a very common injury that occurs as an aftermath of liver surgeries and liver transplantations. It involves major inflammation and is responsible for deaths in the case of transplants and rejections. Oxidative stress can worsen the condition.
CBD has been shown to have therapeutic effects in many major liver diseases, including viral hepatitis, fatty liver disease, ischemia-reperfusion injury, cirrhosis, fibrosis, and liver cancer.
Let’s shed some light on the infamous study on mice.
CBD Oil for Autoimmune Hepatitis
With 1,500 mg of CBD taken for a six-week period, no dangerous side effects were observed (1).
The studies performed on how CBD affects liver function have brought conflicting results.
Now it’s time to ask a different question: what positive effects does CBD have on the liver?
Unfortunately, there are no official dosage recommendations when it comes to CBD and the liver. Most clinical trials that suggest specific dosages of CBD have been performed on anxiety, chronic disorder such as epilepsy, and multiple sclerosis models in humans. No clinical study has yet investigated the efficacy of different doses of CBD on the symptoms of liver disease.
The main concern with CBD is its potential interactions with other drugs . CBD itself is metabolized by an enzyme called CYP3A4. There are prescription drugs that hinder CYP3A4, which can thereby slow the breakdown of CBD and increase its rate of physiological activity. Other drugs increase levels of the enzyme and lead to rapid CBD breakdown.
In 2017, a study by the University of Pennsylvania School of Medicine found that almost 70% of CBD products didn’t contain the amount of the cannabinoid promised on the label. Over 40% contained too little CBD, while 25% contained too much. Even more concerning, almost 20% of the products contained significantly high levels of THC.
CBD Interactions with Prescription Medications
There is scant evidence to suggest that CBD itself causes any issues with liver function at low levels. However, it’s still important to keep some key things in mind. One of the first things to keep an eye out for is low-quality CBD, which may harm your liver by exposing it to toxins.
Is the oil free from pesticides, insecticides, and heavy metals?
Does it post results of third-party lab tests on its site?
June 4, 2019 by Natalie Shae
The FDA has approved a CBD-based drug named Epidiolex®. The drug was researched and made by Greenwich Biosciences, and the company’s vice-president of U.S. professional relations, Alice Mead, has stated to the FDA that CBD is “potentially” a liver toxin. She said this during the FDA’s first public hearing on CBD oil on May 31, 2019.
To further complicate the question, products with CBD oil may not give the exact amount listed on the package . Depending on the brand, the consumer may be using much more or less than they think. This is especially true of OTC supplements and e-cigarettes.
The few studies performed on how CBD affects the liver are not clear.
Because CBD oil is not considered a drug, it can be a common additive in many products. This includes e-cigarettes (vape oil), lotions and various herbal supplements. It has also been shown to relieve symptoms of different disorders like epilepsy, anxiety and multiple sclerosis.