CBD and CBD-containing compounds such as nabiximols were helpful in alleviating psychotic symptoms and cognitive impairment in patients with a variety of conditions, and several studies provided evidence of effectiveness in the treatment of cannabis withdrawal and moderate to severe cannabis use disorder with Grade B recommendation. There is Grade B recommendation supporting the use of CBD for the treatment of schizophrenia, social anxiety disorder and autism spectrum disorder (ASD), and attention deficit hyperactivity disorder (ADHD). Grade C recommendation exists for insomnia, anxiety, bipolar disorder, posttraumatic stress disorder, and Tourette syndrome. These recommendations should be considered in the context of limited number of available studies.
One case report on the use of CBD by two patients with bipolar disorder showed limited to no improvement with doses of 600–1200 mg for bipolar mania in one of the patients (Shannon et al., 2019). The second patient was prescribed CBD 600 mg (5–9 days) and olanzapine (10–15 mg), followed by CBD 900–1200 mg (20–33 days), and showed improvement on the Brief Psychiatric Rating Scale (37% reduction) and Young Mania Rating Scale (33% reduction) with CBD and olanzapine, but no additional improvement with CBD monotherapy (Shannon et al., 2019). This effect was consistent with results from animal studies that modeled acute mania with dextroamphetamine (Shannon et al., 2019). The lack of effectiveness can be attributed to the shorter duration of treatment in both cases. This evidence from studies of bipolar mania should be considered in the context of different pharmacological agents responding differently to certain episodes of bipolar disorder. In animal studies, CBD induced a rapid, persistent antidepressant response by increasing brain-derived neurotrophic factor in the prefrontal cortex (Shannon et al., 2019). Given its possible antidepressant benefits, the role of CBD should be explored in unipolar and bipolar depression.
Materials and method
The search of eight electronic databases and our manual screening method generated 511 results. After the removal of duplicates, titles and abstracts were screened, resulting in the exclusion of 459 articles. Full-text screening of 52 articles was performed, and 23 articles meeting the inclusion criteria were analyzed. Figure 1 summarizes the screening process.
Four of the included studies did not report any adverse effects of CBD among patients with psychosis. CBD was well-tolerated in these patients except for mild transient sedation, hyperlipidemia, and gastrointestinal distress. Patients with schizophrenia had fewer instances of extrapyramidal symptoms, less weight gain, and a lower increase in prolactin levels.
PRISMA Flow Diagram
They’re made by mixing a CBD extract with oil. CBD oils easier to consume because pure CBD or cannabis resin comes as tiny crystals or a sticky, oily, resin — both of which make it difficult to measure the dose accurately.
There are treatment options available — however, they often come with a myriad of negative side-effects, and often don’t work at all.
In order to get to this stage of research, CBD needed to pass similar tests with flying colors. If it failed any of the studies prior to this phase II clinical trial, it wouldn’t have been approved for use in the study.
Other Treatments for Bipolar Disorder
Updated on June 04, 2021
Cost per mg CBD:
There’s no single cause of bipolar disorder. It’s a combination of many factors ranging from genetic inheritance to environmental and social influences.
Treating bipolar disorder is difficult because the cause is hard to determine.
Bipolar disorder affects around 1.6 million Americans. It causes changes in a person’s mood, emotions, energy levels, behavior, and function. People with bipolar disorder experience extreme emotional states known as mood episodes. The complexity of the condition makes it easy to misdiagnose as depression.
Did you try CBD oil for bipolar disorders? Share your thoughts in the comments!
Research suggests that CBD has the potential to reduce pain, lower inflammation, bolster the immune system, improve sleep, and alleviate the symptoms of anxiety and depressive disorders, such as bipolar affective disorder. Studies of the endocannabinoid system are relatively new, but the results are promising.
How Is Bipolar Disorder Typically Treated?
When this network falls out of whack, it may give rise to a range of health concerns. There’s even a medical term, the endocannabinoid deficiency, where the efficacy of ECS is compromised to the point it becomes deficient in its natural cannabinoids.
However, THC is only one of the 115 identified cannabinoids in the cannabis plant. The second major compound, CBD, is non-intoxicating and can actually counteract the psychoactive effects of THC. According to a 2015 study published in the Journal of Psychopharmacology, using CBD has the same antipsychotic and anticonvulsant properties as conventional bipolar disorder medications (2). Considering the lack of intoxicating effects, hemp-derived CBD oil will be a decent pick for bipolar sufferers.
Plant-based cannabinoids mimic the effects of your endogenous cannabinoids, communicating with receptors in the ECS. The ECS is responsible for managing nearly every process and function in your body, including:
However, these medications often have dangerous side effects. For this reason, people have started seeking help in complementary treatments, such as sensory deprivation, elimination of mental stresses, nutritional adjustments, support groups, herbal medicine, and CBD supplementation.