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cbd hemp oil for ulcerative colitis

Ulcerative colitis is a chronic, long-term illness that causes inflammation of the colon and rectum. Symptoms may include diarrhea, rectal bleeding, passage of mucus, and abdominal pain. It is characterized by periods of acute flares when people experience symptoms as well as periods of remission when symptoms stop.

The researchers evaluated whether cannabis or cannabis oil (cannabidiol) was better than placebo (e.g. fake drug) for treating adults with active ulcerative colitis or ulcerative colitis that is in remission. The researchers searched the medical literature extensively up to 2 January 2018.

The study comparing cannabis oil capsules to placebo found no difference in remission rates at 10 weeks. Twenty four (7/29) percent of cannabidiol participants achieved clinical remission compared to 26% (8/31) of placebo participants. The study also showed higher self reported quality of life scores in cannabis oil participants compared to placebo participants. More side-effects were observed in the cannabis oil participants compared to the placebo participants. These side effects were considered to be mild or moderate in severity. Common reported side effects include dizziness, disturbance in attention, headache, nausea and fatigue. No patients in the cannabis oil group had any serious side effects. Ten per cent (3/31) of the placebo group had a serious side effect. Serious side effects in the placebo group included worsening ulcerative colitis and one complicated pregnancy.

Cannabis is a widely used recreational drug that has multiple effects on the body via the endocannabinoid system. Cannabis contains multiple sub-ingredients called cannabinoids. Cannabis and cannabis oil containing specific cannabinoids can cause cognitive changes such as feelings of euphoria and altered sensory perception. However, some cannabinoids, such as cannabidiol, do not have a psychoactive effect. Cannabis and some cannabinoids have been shown to decrease inflammation in animal and laboratory models which suggests it may help people with ulcerative colitis. For example, cannabidiol is one such cannabinoid that has shown anti-inflammatory activity in mice.

The effects of cannabis and cannabidiol on UC are uncertain, thus no firm conclusions regarding the efficacy and safety of cannabis or cannabidiol in adults with active UC can be drawn.There is no evidence for cannabis or cannabinoid use for maintenance of remission in UC. Further studies with a larger number of patients are required to assess the effects of cannabis in UC patients with active and quiescent disease. Different doses of cannabis and routes of administration should be investigated. Lastly, follow-up is needed to assess the long term safety outcomes of frequent cannabis use.

Another study demonstrated [12] a role for cannabinoids in reducing intestinal permeability and reducing inflammation and regulation of intestinal bacteria, especially as it related to alcohol use disorders. All of these factors can play a role in symptomatic flare-ups in patients with IBD.

About 15% of inflammatory bowel (IBD) patients report [3] using cannabis to alleviate their symptoms. It appears that medical marijuana has a place in the treatment of IBD. A recent study [4] showed benefits in using 30g marijuana/month that translated into 21 mg THC and 170 mg CBD per day for each of the 173 patients followed. Cannabis decreased the need for other medications. The use of cannabis oil is reported [5] among IBD adolescent patients in another study. Their perceived health benefits from use were on sleep quality, appetite, and nausea.

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Research on CBD and Crohn’s Disease

The wide variety of CBD products all come with a detailed third-party Certificate of Analysis of potency and contaminants. Better yet, it is certified by the U.S. Hemp Authority, which issues guidelines on stringent hemp processing. Third-party testing, as for most products on this list, is conducted on all Medterra products.

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The oil itself undergoes a process to make it more bioavailable, a nanotechnology