CBD has been shown in clinical studies to help with pain-specific medical conditions including chronic pain, peripheral neuropathy, pain and inflammation, arthritis pain, and myofascial pain. Cannabinoids can also help improve pain in patients receiving palliative care. A 2020 cross-sectional study found that nearly 25% of outpatient palliative care patients use CBD, with topical application being the most common form used.
This article has been medically reviewed by Ashley Jordan Ferira, PhD, RDN, the Senior Editor of Health & Wellness Strategy at Remedy Review, an independent CBD reviews site. Dr. Ferira completed her PhD in Foods & Nutrition at The University of Georgia, where she researched the role of vitamin D in pediatric cardiometabolic disease. The products featured in this article were tested at ProVerde Laboratories in Milford, MA and Avazyme, Inc. in Durham, NC.
Our favorite topical CBD products include soothing creams, balms, salves, and lotions, all of which are made from American-grown hemp and have been independently tested by third-party labs for quality and safety purposes.
Best Cool Therapy: CBDistillery Cooling Cream
Let's dive into our top product recommendations for the best CBD cream for pain. Continue on to learn more about CBD cream usage and selecting the product right for you.
CBD topicals are a great herbal strategy to help with localized aches and pains, and they are generally considered safe to use. However, the FDA has yet to evaluate mainstream CBD skincare products, which is why you should always do your research and aim to purchase from high-quality companies. If you or your loved one are seeking the best CBD cream for pain, our recommendations are a great place to start.
As it turns out, topical CBD products may offer some anti-inflammatory properties to help alleviate pain through cannabinoid receptors within the skin. These receptors are a part of the body's endocannabinoid system, or ECS, that governs functions such as our ability to process pain, as well as inflammation, mood, and sleep. The cannabis plant contains phytocannabinoids like CBD that interact with our ECS, which is why hemp has therapeutic properties.
CBDMedic’s ointment (which is now part of the Charlotte’s Web lineup) is formulated with 200 milligrams of THC-free CBD, plus camphor and menthol to deliver targeted pain relief. It also includes essential oils like clove, cottonseed, jojoba seed, eucalyptus, peppermint, and tea tree to help soothe sore muscles and strains in your upper and lower back, shoulders, and neck.
CBD is emerging as a promising pharmaceutical agent to treat pain, inflammation, seizures, and anxiety without the psychoactive effects of THC. Our understanding of the role of CBD in pain management continues to evolve, and evidence from animal studies has shown that CBD exerts its pain-relieving effects through its various interactions and modulation of the endocannabinoid, inflammatory, and nociceptive (pain sensing) systems. The endocannabinoid system consists of cannabinoid receptors that interact with our own naturally occurring cannabinoids. This system is involved in regulating many functions in the body, including metabolism and appetite, mood and anxiety, and pain perception.
Cannabis (most commonly obtained from the Cannabis indica and Cannabis sativa plants) has three major components: cannabinoids, terpenoids, and flavonoids. While there are over a hundred different cannabinoids, the two major components are tetrahydrocannabional (THC) and cannabidiol (CBD). Historically more attention has been paid to the psychoactive (euphoric “getting high”) component of the cannabis plant, THC; there have been fewer scientific studies on the medical use of CBD, a non-psychoactive component of the plant.
What’s the research that CBD works in humans?
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In fact, the FDA has issued several warning letters to companies and individuals that market unapproved new drugs that allegedly contain CBD. The FDA has tested the chemical content of cannabinoid compounds in some of the products, and many were found to not contain the levels of CBD the manufacturers had claimed they contain.
Most importantly, CBD can interact with other important medications like blood thinners, heart medications, and immunosuppressants (medications given after organ transplantation), potentially changing the levels of these important medications in the blood and leading to catastrophic results, including death. Also, more information needs to be gathered about its safety in special populations such as the elderly, children, those who are immunocompromised, and pregnant and breastfeeding women.