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In another amazing display of the entourage effect, CBC appears to work in conjunction with both THC and CBD to deliver a trifecta of antidepressant properties.

In a 2013 mouse study, CBC had a positive effect on neural stem progenitor cells (NSPCs), a cell essential to healthy brain function. NSPCs became more viable when in the presence of CBC, and that shows promise because NSPCs differentiate into astroglial cells, the most important cells for maintaining brain homeostasis. The astroglial cells perform a whole host of functions, including neurotransmitter direction and defending against oxidative stress. Astroglia counteract many of these issues—oxidative stress, inflammation, toxicity—that create neurological diseases and brain pathologies like Alzheimer’s disease.

A recent study in which tumor growth was initiated in mice (two-stage mouse skin carcinogenesis model) showed cannabinoids might be effective in inhibiting both inflammation and tumor growth. Since anandamide has been shown to fight breast cancer in vitro and in vivo, this shows promise that CBC and other cannabinoids might one day be a chemopreventive agent.

Brain Cells

The purported benefits of CBC have far-reaching implications. Below are a few medical conditions that may be alleviated by cannabichromene.

While CBC definitely has singular benefits, researchers also think that it seems to synergistically work with other cannabinoids, a term known as the entourage effect. This effect of THC and CBD working together is well-known, but whether other cannabinoids have entourage effects is not well understood.

Cannabichromene has been shown to block pain and inflammation associated with collagen-induced osteoarthritis. Cannabinoids like CBC act on inflammation differently than non-steroidal anti-inflammatory drugs (NSAIDs) do, and don’t have the side effects of these medications. In another example of the entourage effect, CBC in combination with THC had significant anti-inflammatory response in a recent animal study; together, the two cannabinoids produced a much greater effect on inflammation than by themselves.

A research team that had previously shown CBD’s effect on acne studied other cannabinoids, including CBC, for the same effects. Indeed, CBC was shown to be a powerful inhibitor of acne. As a skin disease, acne is characterized by excess sebum production and sebaceous gland inflammation. It turns out that CBC exhibited powerful anti-inflammatory properties and also suppressed excessive lipid production in the sebaceous glands. CBC also reduced levels of arachidonic acid (AA), which is needed to create the lipogenesis. More research is needed, but CBC might just one day become a very powerful anti-acne treatment.

Please consult a physician before use.

Our Relief Formula CBC softgels are a full spectrum, whole-plant extract that features a 3:1 ratio of CBD to CBC. Discovered over 50 years ago, CBC is considered one of the “big six” cannabinoids prominent in medical research. It’s thought to have the same potential as CBD as well as its own unique uses.*

View and download your product’s Certificate of Analysis (COA). Locate the batch ID on the product label and click the corresponding link to see the results for your specific item. COAs detail potency, cannabinoid profile, and purity from contaminants.

Suggested Use

10mg of CBC and 30mg of CBD work together to enhance hemp’s whole plant benefits in these convenient Relief Formula softgels.

Start with one capsule per day and increase to up to two capsules daily. We recommend spacing out doses in the morning and evening. Keep in mind that CBD capsules are slower-acting than other methods.* Be prepared for a more subtle, gradual onset.*

Extract Labs is privately owned. When you shop with us, you are purchasing a product made by the hardest working people in the industry. We are all obsessed with making the best CBD products available to everyone. Your hard-earned money doesn’t go into the pockets of investors. It goes towards upgrading equipment to lower product costs, research into new cannabinoids, and helps keep a roof over the heads of our 40-something employees.

The CBD market is still the wild wild west. Anyone can make it, sell it and slap a misleading or even outright false label on their product. With so many brands to choose from, it can be hard to determine who to trust. Instead of just claiming our products are the best, we show you. All of our products are backed by our batch tracking system so you can view a certificate of analysis for the product in your hand. Yes, many companies provide a COA, and some are legit. However, many are showing you an old, irrelevant COA. Even some of the biggest names in the business have gotten busted for inaccurate lab reports! We put a tracking number on all products that you can use to view the COA specific to each batch produced. What about 3rd party testing? Here’s what we can say about that… we are a lab, and we provide analytical services just like other labs, therefore, it is both cost-effective and of a higher quality to use our own facility. This is not a compromise. It is the only way we can provide the best quality and best value possible. Therefore, it is directly in line with our core values and mission as a company. Occasionally, a CBD vetting company will have our products tested by multiple 3rd-party labs, and guess what they find? We have been awarded the highest standards for perfect scores. One company (CBD Examine) went so far as to detail that per cannabinoid volume, our tinctures are the best quality and value on the market.

Izzo AA, Capasso R, Aviello G, et al. Inhibitory effect of cannabichromene, a major non-psychotropic cannabinoid extracted from Cannabis sativa, on inflammation-induced hypermotility in mice. Br J Pharmacol. 2012;166(4):1444-60. View abstract.

Pregnancy and breast-feeding: There isn’t enough reliable information to know if cannabichromene is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.

Hatoum NS, Davis WM, Waters IW, Elsohly MA, Turner CE. Synergism of cannabichromene and CNS depressants in mice. Gen Pharmacol. 1981;12(5):351-6. View abstract.

Side Effects

Cannabichromene has not been studied in humans. But it has been investigated for its anti-inflammatory, analgesic, neuroprotective, and antidepressant effects.

De Petrocellis L, Orlando P, Moriello AS, et al. Cannabinoid actions at TRPV channels: effects on TRPV3 and TRPV4 and their potential relevance to gastrointestinal inflammation. Acta Physiol (Oxf). 2012;204(2):255-66. View abstract.

Udoh M, Santiago M, Devenish S, McGregor IS, Connor M. Cannabichromene is a cannabinoid CB2 receptor agonist. Br J Pharmacol. 2019;176(23):4537-4547. View abstract.

Romano B, Borrelli F, Fasolino I, et al. The cannabinoid TRPA1 agonist cannabichromene inhibits nitric oxide production in macrophages and ameliorates murine colitis. Br J Pharmacol. 2013;169(1):213-29. View abstract.