Pharmacist Brad White will review current research on low-dose naltrexone and CBD Oil and how a compounding pharmacy can be a resource for treating autoimmune conditions like fibromyalgia, IBS, Crohn’s disease, and chronic pain. Combination of cannabidiol with low‑dose naltrexone increases the anticancer action of chemotherapy in vitro and in vivo We previously reported that both cannabidiol (CBD) and low‑dose CBD oil is rising in popularity, and some people have turned to it to replace alcohol. However, it may not be smart to take CBD while using naltrexone
Low Dose Naltrexone and CBD Oil Products Webinars
The Medicine Center Pharmacy is hosting an informational seminar for patients currently taking Low-Dose Naltrexone (LDN) and CBD oil products, or who are interested in learning more about its uses in the treatment of autoimmune disease and chronic pain.
We will review the state of the current research on its effectiveness for various conditions. Both CBD oil products and LDN have prompted many questions at our pharmacy and we are happy to share experiences and feedback with you. We will provide accurate information regarding the potential benefits of LDN and CBD oil from the experiences of our own patients, as well as to provide a forum to connect with others dealing with the difficulties of autoimmune and chronic pain disorders.
This seminar will examine the specific chronic pain conditions for which LDN has been shown to be an effective, non-opioid, treatment option for patients experiencing moderate to severe pain, inclusive of Complex Regional Pain Syndrome (CRPS), Fibromyalgia, Neuropathies, back pain and autoimmune disease. In addition, LDN’s unique ability to control pain in opioid-dependent patients, and assist in the tapering and elimination of opioids, will be reviewed. A comprehensive review of current literature will be discussed, its mechanism of action, as well as the clinical experience gained from the treatment of thousands of LDN patients, to form the clinical indication specific dosing guidance and titration protocols which are essential to achieving therapeutic success for your patients.
Combination of cannabidiol with low‑dose naltrexone increases the anticancer action of chemotherapy in vitro and in vivo
We previously reported that both cannabidiol (CBD) and low‑dose naltrexone (LDN) exhibit complex effects on G‑protein coupled receptors, which can impact the expression and function of other members of this superfamily. These receptors feed into and interact with central signalling cascades that determine the ease by which cells engage in apoptosis, and can be used as a way to prime cancer cells to other treatments. The present study was designed to investigate the effect of combining these two agents on cancer cell lines in vitro and in a mouse model, and focused on how the sequence of administration may affect the overall action. The results showed both agents had minimal effect on cell numbers when used simultaneously; however, the combination of LDN and CBD, delivered in this specific sequence, significantly reduced the number of cells, and was superior to the regimen where the order of the agents was reversed. For example, there was a 35% reduction in cell numbers when using LDN before CBD compared to a 22% reduction when using CBD before LDN. The two agents also sensitised cells to chemotherapy as significant decreases in cell viability were observed when they were used before chemotherapy. In mouse models, the use of both agents enhanced the effect of gemcitabine, and crucially, their use resulted in no significant toxicity in the mice, which actually gained more weight compared to those without this pre‑treatment (+6.5 vs. 0%). Overall, the results highlight the importance of drug sequence when using these drugs. There is also a need to translate these observations into standard chemotherapy regimens, especially for common tumour types where treatment is often not completed due to toxicities.
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Can You Take CBD Oil With Naltrexone?
As the move to legalize marijuana continues its momentum, new medical uses for this substance seem to be popping up left and right. Cannabidiol (CBD), one of the better known components of marijuana, has shown promise as a treatment for seizures, insomnia, and certain types of chronic pain. According to other initial studies, it may even help some people drink less alcohol.
But does this mean you should take CBD oil to help you quit drinking? And what if you’re already taking anti-craving medications like naltrexone? Does CBD mix well with other medications for alcohol addiction?
Some initial studies combining CBD and low-dose naltrexone (LDN) show encouraging signs, but that doesn’t mean you should go running to your local dispensary just yet. Here are the facts, as we currently know them, about combining CBD with naltrexone treatment.
Can CBD Really Help With Alcohol Cravings?
To begin with, it’s important to look at the evidence for CBD as a treatment for alcoholism. Marijuana maintenance—using cannabis to help you cut back or quit alcohol—has been trending for some time. However, the research around marijuana as a way to reduce alcohol cravings is still limited. And there are always risks to replacing one substance with another.
CBD may seem like an appealing alternative to smoking weed for alcohol cravings. Cannabidiol on its own seems to have little to no intoxicating effects, so it’s not likely you’d replace one addiction with a different one. And skipping out on some of the common side effects of regular marijuana could be an added benefit.
But does it actually work? And is it actually free from risk? A 2019 review of the evidence suggests that CBD may reduce the motivation to drink, and how much you drink. It may also reduce anxiety, impulsivity, and the likelihood of relapse. Finally, CBD might even help with alcohol-related brain and liver damage. It could be an excellent all-around drug for helping people recover from alcohol addiction.
But here’s the kicker: All of the studies included in this review were on animals. Not enough is known about CBD and humans. In one 2021 observational study on people, those who consumed CBD-heavy strains of marijuana drank less than those who used balanced or more THC-heavy strains. But a lot more studies need to be carried out with human subjects before CBD is actually FDA-approved for this purpose.
In summary, there are reasons to believe that CBD oil for alcohol cravings could be helpful. But there is still a lot we don’t know, and we cannot actually recommend it yet.