Can You Get CBD Oil On Prescription In The Uk

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Cannabis-based products for medicinal use: Frequently asked questions

A set of clinical frequently asked questions (FAQs) to provide further support to prescribers.

There are three broad requirements that a product should satisfy:

  • The product is or contains cannabis, cannabis resin, cannabinol or a cannabinol derivative
  • It is produced for medicinal use in humans; and
  • It is a product that is regulated as a medicinal product, or an ingredient of a medicinal product.

The definition is necessarily broad to take account of the range of preparations which are cannabis-based that have been used for therapeutic purposes and to ensure that raw products/ingredients and intermediate products are captured. This is essential to ensure that where there is a clinical need, a patient will be able to access appropriate cannabis-based medicines and/or products can be made to meet any prescription.

‘Pure’ cannabidiol (CBD) only based products (including synthetic versions) are not classified as a cannabis-based product for medicinal use and are not controlled drugs as they contain very small amounts of THC. To be exempt from scheduling a product will need to fulfil the three limbs of the Exempt Product definition as outlined in the law.

There are three main groups of chemical compounds that fall within the broad category of ‘synthetic cannabinoids’:

  • Synthetic compounds which are identical in structure to naturally occurring cannabinoids such as delta-9-tetrahydrocannabinol (THC) e.g. Dronabinol.
  • Synthetic compounds structurally related to naturally occurring cannabinoids that have been developed to mimic naturally occurring cannabinoids such as THC e.g. Nabilone.
  • Synthetic compounds not structurally related to naturally occurring cannabinoids but which bind to cannabinoid receptors in the body.

With respect to group 1 compounds, Dronabinol has been developed as a medicinal product. Dronabinol is not available as a licensed medicine in the UK. In addition, in group 2, Nabilone has also been developed for medicinal use and is available as a licensed medicinal product. Group 3 synthetic compounds not structurally related to naturally-occurring cannabinoids but which bind to cannabinoid receptors in the body are not available as licensed medicinal products. Many of the compounds in group 3 have frequently been found in illicit street products referred to by the street names of Spice and Black Mamba and are predominantly new psychoactive substances (NPS). There is clear evidence of significant harm and several deaths associated with their illicit use.

The Advisory Council on the Misuse of Drugs (ACMD) has particular concerns with compounds falling within group 3 and others within group 2, with the exception of Nabilone, and is of the view that further research into this complex group of diverse substances is important, given the associated potency and harms.

This group of new psychoactive substances is being considered by the ACMD as part of their longer-term review.

Due to the limited evidence base and their unlicensed nature, prescribing of cannabis-based products for medicinal use is restricted to only those clinicians listed on the Specialist Register of the General Medical Council.

Any decision to prescribe must take into account the relevant GMC guidance and the relevant NHS Trust governance procedures for unlicensed medicines in the normal way. In addition, a Specialist on the General Medical Council Register should only prescribe within their own area of practice and training, and the decision to prescribe should generally be agreed by the multidisciplinary team. Adhering to the normal medicines governance systems not only supports good clinical practice but also offers liability coverage for NHS employees in prescribing an unlicensed medicine and importantly, is safer for patients.

A GP may make a referral to a specialist doctor on the General Medical Council’s ‘Specialist Register’ once the patient reaches the appropriate point in their treatment pathway.

The law requires that these products be supplied under either the prescription or direction of a clinician on the General Medical Council’s Specialist Register. It is important to ensure that clinical specialists with the appropriate expertise are able to make treatment decisions in their patient’s best interest, and that decisions about prescribing are in the hands of expert clinicians led by evidence on quality, safety and effectiveness, balancing the benefits that might be accrued for a particular patient against the products proven harms.

Private Doctors who are on the General Medical Council’s specialist register are now legally able to prescribe cannabis-based products for medicinal use. This is the same for NHS and private providers. In the NHS, decisions to prescribe should generally be the result of multidisciplinary discussion. The Chief Medical Officer expects clinicians in a non-NHS setting to follow equivalent processes for prescribing unlicensed special medicines.

Specialist Doctors, whether working for the NHS or not, will receive support and guidance on the evidence for the use of cannabis-based products for medicinal use, and the circumstances in which they may be prescribed. This is in the form of the interim clinical guidance (from the BPNA, RCP and ABN), the MHRA specials guidance and the NICE clinical guideline.

Prescribing by both private and NHS providers will be monitored by local controlled drugs accountable officers.

Specialist doctors wishing to prescribe this privately outside of a hospital environment will need to contact the local lead Controlled Drugs Accountable Officer for a Prescriber Identification Number.

The law requires that these products be supplied under either the prescription or direction of a clinician on the General Medical Council’s Specialist Register.

However, whilst it is possible for a GP to continue prescribing legally, it is advised that all prescriptions will need to be initiated and signed by a specialist doctor. Consideration will be given to how shared care arrangements should or could work, including determining whether it is indeed appropriate to have such arrangements in place. If a doctor prescribes a medicine under shared care arrangements, he or she accepts clinical and professional responsibility for that prescribing decision.

The law has been drafted such that a specialist needs to be responsible for the decision to prescribe. However, the law does allow other prescribers to continue prescribing once the decision to prescribe has been made by a specialist.

There are existing arrangements permitting doctors not on the specialist register but working under the direction of a specialist within a hospital setting (e.g. speciality registrars, supplementary prescribers, non-medical independent prescribers etc.) to continue prescribing, once patients have become established on a particular treatment with no problems.

In general, however it is expected that patients receiving these products to remain under the direct care of a specialist doctor (i.e. initiation and continued prescribing) in the first instance.

Private prescriptions from outside the UK will not be permissible as the law indicates that prescribing of cannabis-based products for medicinal use is restricted to only those clinicians listed on the Specialist Register of the General Medical Council.

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UK Regulations mean that Schedule 2 and/or 3 controlled drugs and unlicensed medicines may not be supplied on a prescription authorised by an EEA practitioner. This is not unique to cannabis. In addition any prescription that does not comply with the UK requirements cannot be used to lawfully import a product for personal use from another jurisdiction.

As with prescribing any other unlicensed medicine, it is a clinical decision to determine the most appropriate medication or course of treatment to prescribe for a patient, having taken into account the patient, the clinical condition, the clinical evidence of efficacy and safety and the suitability of licensed medicines.

The National Institute for Health and Care Excellence (NICE) has published a clinical guideline on the prescribing of cannabis-based products for medicinal use in humans. This guidance was published in November, with further Technology Appraisals on use of Epidyolex® published in December 2019. These include recommendations for:

  • people with chronic pain
  • people with intractable nausea and vomiting
  • people with spasticity
  • people with severe treatment-resistant epilepsy.

In the interim to this guidance being published the British Paediatric Neurology Association (BPNA) had developed clinical advice on the use of cannabis-based products for medicinal use in paediatric patients with certain forms of severe epilepsy, and the Royal College of Physicians (RCP) had developed additional advice around prescribing of cannabis-based products for medicinal use in intractable chemotherapy induced nausea and vomiting, and chronic cancer pain.

The Association of British Neurologists (ABN) had developed guidance on the use of cannabis-based products for medicinal use in adult patients with neurological conditions. This guidance is now available and covers use in rare epilepsies and MS related spasticity.

Advice produced by the Professional Organisations has now been superseded by issuing of the NICE guidance as outlined above

No. Doctors should always first consider prescribing medicines that are licensed for the specific condition that the patient presents with. This is because these products have been tested for quality, safety and efficacy by the regulators for the indication they are prescribed for and are subject to the quality assurance arrangements that apply to all licensed medicines when they are manufactured. If this is not possible then the next option would be an off-label use of a licensed medicine, again because these will have been subject to those quality assurance arrangements, but the doctor has to be confident that the medicine would be appropriate for the specific indication and the patient, that it is being prescribed for.

Prescribing an unlicensed product should be considered third and only if an individual patient has exceptional clinical needs that cannot be met by a licensed or off-label medicine.

The BPNA guidance recommends that CBD (Epidiolex®) should be the default choice when considering prescription of a cannabis-derived medicinal product in intractable epilepsy in children. They do not recommend prescribing other non-licensed cannabis-derived medicinal products, which includes all artisanal cannabis oils, whether or not they comply with good manufacturing practice (GMP) or good distribution practice (GDP) standards.

Cannabidiol oral solution (Epidyolex®) is a CBD product that has been through randomised controlled trials for two epilepsy syndromes (Dravets syndrome and Lennox-Gastaut syndrome). It has recently been approved for a European marketing authorisation by the European Medicines Agency (EMA) for the treatment of seizures associated with Lennox-Gastaut syndrome or Dravet syndrome. From 1 October 2019, Epidyolex® will be classified as a Schedule 2 controlled drug (CD) in the UK rather than being exempt from scheduling (an ‘Exempt Product’). This change is being made to reflect the trace levels of THC in the medicine. Prior to licensing, Epidyolex® was available through compassionate use and extended access programmes. These are now closed to new patients.

NICE has published Technology Appraisals for the use of cannabidiol (Epidyolex®) for severe treatment-resistant epilepsies. The appraisals look at the clinical and cost effectiveness of cannabidiol in conjunction with clobazam for adjuvant treatment of seizures associated with Lennox-Gastaut and Dravet syndromes. Both appraisals recommend cannabidiol with clobazam as an option for treating seizures associated with these syndromes in people aged 2 years and older, subject to adequate monitoring and supply arrangements.

Because the only evidence for efficacy and safety in childhood epilepsies relates to use of pure cannabidiol (Epidyolex®). Currently there is no good evidence that products that contain THC are either safe or efficacious and there is a concern about the effect of THC on the developing brain. There is evidence that chronic high exposure to THC during recreational cannabis use can affect brain development, structure and mental health.

Cannabis has many active chemical constituents and two of these constituents, tetrahydrocannabinol (THC) and cannabidiol (CBD) have been investigated the most in respect of their medicinal value. THC is the major psychoactive constituent of cannabis and is considered responsible for giving so called “highs” to users of cannabis. CBD on the other hand, is not psychoactive. “Pure CBD” is not a controlled drug for the purposes of the 1971 Misuse of Drugs Act.

Products falling within Schedule 2 will contain varying quantities and ratios of THC and CBD and may be available in a range of pharmaceutical forms.

The BPNA advise that any child who is already taking a cannabis-based product for medicinal use containing THC that is having an apparently beneficial effect should transition to pure cannabidiol (Epidyolex®) as there is stronger evidence of effectiveness and a lower risk of long-term side effects than for products containing THC. However as with all treatment decisions, it is ultimately the responsibility of the patients’ Paediatric Neurologist, in discussion with the patient and their family, to determine the best treatment options, taking into account the emerging evidence and the patients’ individual clinical circumstances.

The recommendations have been jointly produced by the Royal College of Physicians (RCP), the Royal College of Radiologists (RCR) and in liaison with the Faculty of Pain Medicine of the Royal College of Anaesthetists. The guidance covers cannabis-based products for medicinal use for chemotherapy induced nausea and vomiting and chronic pain (cancer pain and chronic neuropathic pain).

They recommend that for chemotherapy induced nausea and vomiting, cannabis-based products for medicinal use should remain an option for those who have failed standard therapies. They should not be used as a first-line treatment. They do not recommend use of cannabis-based medicinal products for chronic pain as there is no robust evidence supporting this.

The current evidence for use of cannabis-based products for pain is not sufficiently developed yet; whilst individual patients may perceive benefit; this hasn’t been fully tested in comparative randomised controlled trials in large numbers of patients. Potential harms of using cannabis-based treatments for medicinal use in the long term have also not been studied. There are currently no licensed cannabis-based products available for use in pain.

A recent Cochrane review for neuropathic pain states that ‘there is a lack of good evidence that any cannabis-derived product works for any chronic neuropathic pain’

Rescheduling of these products makes it easier for clinical trials to take place to support furthering our understanding, as the evidence base develops following more research being carried out and as products become licensed, this position will be reviewed.

The ABN guidance recommends that for both Dravets syndrome and Lennox-Gastaut syndrome the BPNA guidance is consulted and they recommend that cannabidiol should be prescribed in these cases.

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For other types of epilepsies, they recommend that at present that there is either no or very little evidence for benefit in other forms of epilepsies. Until there is more evidence the ABN guidance advises extreme caution if these products are being considered for any other form of epilepsy.

The RCP guidance covers use in chronic neuropathic pain which is the predominant type of pain that MS patients experience. Use for chronic pain is currently not recommended as there is insufficient evidence.

There is also some evidence for use of cannabis-based products for MS related spasticity, as outlined in the CMO report. There is a licensed product available in the UK for use in MS related spasticity – Sativex®. This has been through the licensing process and should be used over any unlicensed cannabis-based products for medicinal use; NICE have now published a guideline on Cannabis-Based Medicinal Products. The guideline recommends offering a 4-week trial of THC:CBD spray (Sativex®) to treat moderate to severe spasticity in adults with multiple sclerosis, if other pharmacological treatments for spasticity are not effective.

In Scotland, the manufacturer has never made a submission to the Scottish Medicines Consortium and so Sativex® is not routinely available. In Wales Sativex® is available for use for MS related spasticity.

The ABN guidance suggests that cannabis-based products for medicinal use are used only in people who have had an unsatisfactory response to conventional spasticity drugs e.g. Sativex® – noting NICE and equivalent guidelines on use.

In line with routine clinical practice patients may wish to seek a second opinion and should be supported to do so. Clinicians should refer patients for a second opinion using their established protocols. Further information for patients on second or further opinions is available via the NHS website.

If it is not possible to obtain a second or further opinion using established protocols then please contact your NHS England Regional Medical Director who will be able to offer further advice around a referral route.

No medicine is completely risk free. In the case of products supplied as part of a clinical trial or which is the subject of a Marketing Authorisation, the Medicines and Healthcare Products Regulatory Agency (MHRA) will have assessed the product in line with its normal procedures for safety, quality and efficacy.

Like all other unlicensed medicines imported into or manufactured in the UK, products can only be sourced from reputable suppliers and manufacturers licensed by the MHRA or equivalent organisations of the country from where the product is being sourced. Licence holders in the UK are inspected for compliance with good manufacturing practice standards.

No. These are special medicines and any supplier that has the appropriate MHRA and HO licences and meets the conditions set out in the MHRA guidance can supply. MHRA and DHSC have provided information to Procurement Lead Pharmacists in the NHS. DHSC will keep this information updated until supply becomes established.

Further information will be available from local Procurement Lead Pharmacists.

By rescheduling, we are making it easier to conduct clinical trials on these products. The evidence base for these products is still developing and these changes to the law will encourage further research. The National Institute for Health Research has now issued a call for research proposals to increase our knowledge in this area. The call covers proposals for primary clinical research to evaluate the safety and clinical efficacy or clinical effectiveness of cannabis-based products for medicinal use in humans and was open until July 2019. Applications are currently being considered.

NHS England has commissioned and developed an e-learning training with Health Education England and the University of Birmingham, on cannabis and cannabis based products for medicinal use which all healthcare professionals can access.

This package includes the pharmacology of cannabis, legislation governing medical use and therapeutic areas and evidence for its use. The module will be updated as more information becomes available.

In March 2019, the Secretary of State for Health and Social Care commissioned NHS England and NHS Improvement to review NHS systems and processes to identify and recommend any action necessary to address any barriers to clinically appropriate prescribing of cannabis-based products for medicinal use (CBPMs) on the NHS. The findings and recommendations are available in the document ‘Barriers to accessing cannabis-based products for medicinal use on NHS prescription‘.

The report outlines a number of recommendations aimed at addressing the barriers to clinically appropriate prescribing. These include the establishment of a UK-wide paediatric network to support discussion of complex cases and assist in evidence generation, clinical trials (pending ethical review) and an alternative study for those already in receipt of a CBPM. NHS England and NHS Improvement will work with other national organisations to implement the recommendations and ensure that where it is clinically appropriate, clinicians feel supported to prescribe a cannabis-based product for medicinal use on the NHS.

The Refractory Epilepsy Specialist Clinical Advisory Service (RESCAS) is an independent specialist clinical network that provides evidence-based advice to clinicians treating patients with refractory epilepsy. This UK-wide panel is able to provide advice impartially on a range of treatment options for individuals with refractory epilepsy, based on clinical evidence, knowledge and experience.

This ‘clinician to clinician’ support and advice is available to tertiary paediatric neurology consultants, who jointly care for patients with other clinicians, as part of a multi-disciplinary team.

The advisory network is independent and is hosted by Great Ormond Street Hospital for Children NHS Foundation Trust.

Can you get CBD on prescription?

CBD is available on prescription in the UK, but the process can be time consuming and expensive. The latest National Institute for Health and Care Excellence (NICE) guidelines have prevented the NHS from supplying anything but a small selection of licensed cannabis-based products.

However, the introduction of several private cannabis clinics means that a range of CBD and cannabis products can be prescribed if a specialist doctor believes it’s the only practical option.

CBD products on this site are sold as food supplements. They are not intended to assist with the diagnosis, prevention, treatment, or cure of any disease, ailment or medical condition. Any statements provided on this site are for information only and do not constitute medical advice. Read our full legal disclaimer for more information.

What products are available?

In the UK, cannabis-based products for medicinal use in humans’ (CBPM) fall into two main categories.

Licensed CBPMs

These are medicines that have been trialled and approved by the MHRA for specified uses. There are three cannabis-based medicines licensed for use in the UK:

  • Epidyolex (aka epidiolex) – This is a pharmaceutical preparation of CBD designed for oral consumption. It has 100mg per ml, which is about 10%. The pure CBD is mixed with sesame oil, dehydrated alcohol, strawberry flavour and sucralose. Specialists can only prescribe Epidyolex for seizures associated with Lennox-Gastaut syndrome and Dravet syndrome.
  • Sativex – This is a mouth spray produced from cannabis with a 1:1 ratio of THC to CBD. A specialist can prescribe it for moderate to severe cases of the muscle stiffness caused by Multiple Sclerosis.
  • Nabilone – Also known as Cesamet, this is a synthetic cannabinoid that can be prescribed by a specialist if other medicines are unable to reduce the severity of the nausea and vomiting caused by chemotherapy.

Because these medicines are licensed, their use is strictly controlled. Unless you’re receiving specialist treatment for one of the conditions mentioned, you won’t get a prescription for them.

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Unlicensed CBPMs

An unlicensed medicine hasn’t yet been through the authorisation process, or is being used for a different reason to that outlined in the license. Medications like this will only be prescribed after careful consideration by a multidisciplinary team of specialists. They must look at the evidence available and decide if an unlicensed medicine is the best option.

Despite the slightly worrying term ‘unlicensed’, these products are produced to strict MHRA standards and sourced from pharmaceutical companies. There may not be enough evidence to apply for a license, but they won’t be prescribed unless the prescriber has weighed up all the options.

Unlicensed cannabis-based medications available in the UK include:

  • Cannabis flower
  • Hemp flower
  • Cannabis oil
  • CBD oil (doctors can prescribe higher daily amounts than is allowed by the current FSA guidance for CBD food supplements.)
  • Capsules
  • Sprays
  • THC and CBD products for vaporising

If you receive a prescription for an unlicensed cannabis-based medication, the type and cannabinoid content of what you receive will depend on what your specialist doctor thinks is appropriate for your condition. They will write the prescription and the pharmacy will try to source it. With several specialist cannabis clinics opening in the UK, it’s more likely that you’ll be able to find a pharmacy that can fill your prescription.

Who is eligible for a prescription?

You’re eligible for a prescription for a CBPM or CBD oil if a specialist doctor believes that it’s the most appropriate medication for your condition. This is likely to be after you’ve tried several other options and your remaining choices are limited.

However, you’re only likely to receive a prescription from a private specialist doctor or a cannabis clinic. This is because NHS doctors follow the guidelines outlined by the National Institute for Health and Care Excellence (NICE). These currently recommend that:

  • Doctors should not prescribe CBD or THC for chronic pain.
  • Nabilone may be used for specific cases of nausea and vomiting.
  • Sativex is appropriate for some adults with MS.
  • Epidiolex should only be used as part of a scientific study.

If you choose to pay for a consultation with a private specialist, they may prescribe a CBPM if you have one of the following conditions:

Cancer-related appetite loss

Inflammatory bowel disease

Irritable bowel syndrome

Autistic spectrum disorder

Alzheimer’s disease symptoms

Chronic fatigue syndrome

Traumatic brain injury

Multiple Sclerosis Neuropathic pain

Functional neurological disorder

Motor neurone disease

Muscular dystrophy symptoms

Degenerative disc disease

Spinal cord injury/disease

Post-operative surgery pain

Sleep disorder Posttraumatic stress disorder

Having a diagnosis for one of these conditions does not automatically qualify you for a CBD or medical cannabis prescription. But, if you’ve unsuccessfully tried conventional medications and there are no more available to you, you may be eligible.

How can I get a prescription?

If you’ve exhausted all other options to treat your condition, you can book a consultation with a private specialist doctor or cannabis clinic. Although any doctor on the special register of the General Medical Council can legally prescribe CBPM, some may be reluctant to and might not have access to pharmacists who can fill the prescription. The best option is cannabis clinics staffed by specialist doctors who can guide you through the process and fill your prescription.

In most cases, the cost of a private consultation, repeat appointments and medication can range from a total of between £200 to £450 per month. The medicine itself is costly because multiple companies are involved from farming to production and delivery. At each stage, extra costs are added, resulting in an expensive end product. However, there are now a small number of companies who own every step of the process so are able to keep the costs down.

Although the process differs with each clinic, these are the likely steps involved:

  1. Find a clinic. Several options can easily be found on Google.
  2. Visit their website and complete the online form. They will likely want to collect personal and medical details, including permission to access your records.
  3. If you’re accepted to the next stage, you should receive information on how to pay for and book an appointment.
  4. Attend the appointment. This will be with a specialist doctor and may be over the phone or in person. It will likely involve a discussion about your condition and possible treatment.
  5. If they decide to prescribe you a CBPM, they will talk you through the options, including possible strengths and strains. If you want a CBD-only product such as CBD oil you can discuss this with the doctor at this point.
  6. Most clinics will now pass your prescription to their pharmacy who will contact you to arrange payment.

You may be eligible for a subsidy with Project 21

Project 21 is an ambitious research project that aims to create a large body of evidence on the effects of cannabis-based medicinal products. To do this, they hope to recruit more than 20,000 participants and offer them a £150 per month subsidy towards the cost of private medical cannabis.

To be accepted, you must have a history of at least two prescribed medications, that failed to manage your condition effectively and a diagnosis of at least one of these conditions:

  • Anxiety Disorder
  • Chronic Pain
  • Multiple Sclerosis (MS)
  • Post-Traumatic Stress Disorder (PTSD)
  • Substance Use Disorder
  • Tourette’s Syndrome

If you’re eligible for Project 21, you’ll still need to make an appointment with a clinic and follow the steps above to be assessed for a prescription. However, there is a list of approved Project 21 partners that are the best place to start.

What is the difference between prescribed CBD and CBD food supplements?

CBD oils and other products with concentrations ranging from 1% to 50% are already legal and available in the UK. There are also many brands whose products undergo third-party lab tests and meet high quality and safety standards.

The difference with prescribed CBD is that a doctor will match a specific product and strength to your diagnosis. Because it’s an unlicensed medicine, they aren’t bound by the same restrictions as retailers are for food supplements. They can prescribe daily amounts that could even be as much as 1000mg if they consider it necessary. They could even prescribe a product with a higher level of THC if they believe that it’s the best course of action for you.

Currently, prescription CBD oils are likely to be slightly more expensive than food supplements and they have the additional cost of private doctors’ appointments. However, clinics and suppliers are working together to bring the prices down and make it more accessible for those who need it.

Conclusion

Since the legalisation of medical cannabis in 2018, it’s taken a disappointingly long time for genuine patients to be able to access the treatment they need. However, now things are moving faster. If you go private, you can get an appointment with a specialist doctor with the ability to prescribe CBD oils and cannabis-based medications.

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Tom Russell

Tom Russell writes extensively about CBD oil and other groundbreaking food supplements. He and his wife share their home with two daughters and a lifetime’s collection of books.

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