CBD has a remarkably good safety profile. Researchers have tested the efficacy and safety of CBD in humans using doses as high as 1,500 mg – 3000 mg CBD daily.
It goes without saying that CBD — like any supplement or medication — does have side effects, including dose-dependent danger to liver health. However, while users using the peak-tested dosages should have their liver enzymes in check, the vast majority of people can safely use CBD without worrying about a negative impact on their liver function.
The Study on CBD and the Liver of Mice
CBD has been shown to have anti-fibrosis properties by eliminating cells that secrete collagen and cause fibrosis. It can also reverse alterations in the liver associated with alcohol-induced injury (9).
CBD has been shown to have therapeutic effects on the models of viral hepatitis, especially Hepatitis C. According to a study published in the journal Pharmacognosy Research, CBD was shown to inhibit the replication of hepatitis C virus by almost 90% (5).
Autoimmune hepatitis results from a weakened immune system that attacks the liver. Again, inflammation is the key player in the development of this disease. One study has reported that the activation of TRPV1 vanilloid receptor — part of the ECS — lowers inflammation by activating myeloid-derived suppressor cells (MDSCs). These cells, in turn, block inflammation and the development of autoimmune hepatitis.
This can be done by consuming CBD oil and closely monitoring the symptoms for improvement.
It is necessary to consult the doctor before starting the use of CBD to prevent unwanted side effects due to dose and drug interaction.
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Dosage and Usage
Users should always use a high-quality product obtained from good sources. Cheap oils can be adulterated and result in toxicity.
CBD was shown to attenuate alcohol-induced liver injury in mice models that were fed alcohol.
It was seen that CBD administration over a month could reserve the cognitive and motor impairment. This was attributed to the down-regulation of A(2)A adenosine receptor.
CBD oil or cannabidiol oil is the term given to the yellowish fluid derived from the industrial hemp or marijuana plant (Cannabis sativa).
How much CBD is too much?
To further complicate the question, products with CBD oil may not give the exact amount listed on the package . Depending on the brand, the consumer may be using much more or less than they think. This is especially true of OTC supplements and e-cigarettes.
We support health writers who wish to spread their work to a wider audience. This article was submitted by Natalie Shae.
As determined by the studies done on Epidiolex®, CBD is metabolized by the liver. People with nonalcoholic steatohepatitis (NASH) are encouraged to limit over-the-counter (OTC) medications to avoid stressing the liver.
Because CBD oil is not considered a drug, it can be a common additive in many products. This includes e-cigarettes (vape oil), lotions and various herbal supplements. It has also been shown to relieve symptoms of different disorders like epilepsy, anxiety and multiple sclerosis.
What is CBD oil?
Note, the study cited in the article was very small with children under physician care but if you are a liver patient it is a cautionary note if you are considering CBD oil. We are not aware of any research that would suggest using it more broadly but consult your doctor.