Animal studies showed that topical CBD applications relieve pain and inflammation associated with arthritis with few side effects. The topical application of CBD is beneficial because CBD is poorly absorbed when taken by mouth and can cause gastrointestinal side effects. 6
Medically reviewed by Carmen Fookes, BPharm. Last updated on Nov 2, 2020.
CBD (short for cannabidiol) is one of over 200 chemical compounds known as cannabinoids that are found in cannabis. It is the second most prevalent active compound found in cannabis, behind THC (tetrahydrocannabinol), which is the compound in cannabis that has psychoactive properties and gives people a high. 2
Conclusion: Topical CBD may be beneficial at relieving arthritis but no high-quality human studies prove this.
In addition, more trials are needed to investigate its use for numerous other conditions, such as muscle-spasticity in multiple sclerosis, Alzheimer’s disease, substance-abuse treatment, and diabetes protection.
Instead, CBD is thought to influence other receptors, including opioid receptors that regulate pain and glycine receptors involved in the regulation of the “feel-good” hormone and neurotransmitter serotonin.
CBD oil may benefit those with drug addiction, suggests a 2015 review of studies published in Substance Abuse.
There is currently no known “correct” dose of CBD oil. Depending on individual needs and what is being treated, the daily dose may range between 5 and 25 mg.
CBD is the short name for cannabidiol, one of the two chemicals—among the dozens in cannabis—that have the most health benefits. The other, tetrahydrocannabinol (THC), produces the psychoactive effects described as being “high.” CBD oil generally does not contain THC, although some trace amounts may be present in products sold in certain states.
CBD oil can interact with certain medications, including some drugs used to treat epilepsy. CBD inhibits an enzyme called cytochrome P450 (CYP450), which metabolizes certain drugs. By interfering with CYP450, CBD may either increase the toxicity or decrease the effectiveness of these drugs.
Summary: No proof – there lacks enough academic research to prove this.
Generally, doctors advise people with chronic anxiety to avoid marijuana because THC can trigger paranoia or increase anxiety. However, CBD can help with both anxiety and depression if the THC level is limited to 0.03%.
According to researchers, current cannabis users, over 4600 test subjects had fasting insulin levels up to 26% lower than those who didn’t use cannabis. They also had higher levels of HDL cholesterol that helps protect against diabetes and 17% lower insulin levels of resistance.
15.3 Increased Effectiveness
Summary: Effective – Academic research proves that CBD can help treat lupus.
Our skin has the highest concentration and amount of CB2 receptors of all other organs of the body. Several studies show that CBD oil has a high likelihood of treating certain skin conditions  like acne and eczema by encouraging abnormal cell death.
Summary: Effective – Academic research proves that CBD can help alleviate cancer-related symptoms.
It is often a physical response to injuries in the wall lining of the arteries, caused either by infectious microbes, high blood pressure, or excessive presence of homocysteine, an amino acid. Studies show that inflammatory molecules can stimulate a cycle that leads to atherosclerotic lesion.